Evidence map›Paper›PMID 30519089›Full record

ArticleCancer management and research2018

Prognostic significance of combined preoperative platelet-to-lymphocyte ratio and lymphocyte-to-monocyte ratio in patients undergoing surgery with stage IB non-small-cell lung cancer.

Yongqiang Chen, Weidong Wang, Xuewen Zhang, Xiangyang Yu, Kexing Xi, Yingsheng Wen, Gongming Wang, Xiaoli Feng, Lanjun Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer management and research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
1.2field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Yongqiang ChenDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Weidong WangDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Xuewen ZhangDepartment of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
Xiangyang YuDepartment of Thoracic Surgical Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, National Cancer Center, Beijing, China.
Kexing XiDepartment of Thoracic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Yingsheng WenDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Gongming WangDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Xiaoli FengDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Lanjun ZhangDepartment of Thoracic Surgery, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China, zhanglj@sysucc.org.cn.
Sun Yat-sen University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundResearch indicates that the presence of a systemic inflammatory response plays an important role in predicting survival in patients with cancer. The aim of this study was to investigate the prognostic value of preoperative neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index, and the combination of preoperative LMR and PLR (LMR-PLR) in predicting the survival of patients with stage IB non-small-cell lung cancer (NSCLC). MATERIALS AND

methodsWe retrospectively analyzed clinical data of 577 patients with stage IB NSCLC who underwent pneumonectomy from January 1999 to December 2009. Univariate and multivariate Cox survival analyses were used to evaluate the prognostic indicators, including LMR-PLR. The cutoff values for LMR and PLR were defined by the receiver operating characteristic (ROC) curve analysis. According to the ROC curve, the recommended cutoff values of LMR and PLR were 3.16 and 81.07, respectively. We divided the patients into three groups according to their LMR and PLR status and defined them with different scores. Patients with both high LMR (>3.16) and low PLR (≤81.07) were given a score of 2, whereas those with one or neither were scored 1 or 0, respectively. Survival curves were plotted using the Kaplan-Meier method and compared with the log-rank test. Cox proportional hazards analyses were used to identify the factors associated with overall survival (OS).

resultsThe median follow-up time was 93.77 months. The allocation of the LMR-PLR score was as follows: LMR-PLR = 0, 193 (33.4%) patients; LMR-PLR = 1, 308 (53.4%) patients; and LMR-PLR = 2, 76 (13.2%) patients. After multivariate analysis, our results showed that LMR-PLR was an independent prognostic indicator for OS (

conclusionThis study demonstrated that preoperative LMR and PLR are simple, readily available, and low-cost biomarkers. Preoperative LMR-PLR score can be used as a valuable prognostic marker for long-term survival in stage IB NSCLC patients who underwent surgery.

Indexed as

IB non-small-cell lung cancerlymphocyte-to-mono-cyte ratioplatelet-to-lymphocyte ratiopneumonectomyprognostic factorssystemic inflammation

Identifiers

PMID30519089
PMCPMC6234992
OpenAlexW2899581704

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.