ReviewJournal of pain research2018
Gender, genetics, and analgesia: understanding the differences in response to pain relief.
Review in Journal of pain research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pharmacodynamic characteristics and influencing factors of tapentadol for chronic pain relief under dose titration.Frontiers in pain research (Lausanne, Switzerland) · 2024Pooled it
- Fibromyalgia in obstructive sleep apnea-hypopnea syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2024Pooled it
- Trial
- Postobturation Pain of three Novel Calcium Silicate-based sealers with asymptomatic irreversible pulpitis or necrotic pulp with chronic apical periodontitis: prospective clinical trial.BMC oral health · 2024Trial
- Effect of topical local anaesthesia on injection pain associated with administration of sterile water injections - a randomized controlled trial.BMC anesthesiology · 2022Trial
- Differential Analgesia From Vibratory Stimulation During Local Injection of Anesthetic: A Randomized Clinical Trial.Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] · 2020Trial
- Spinal NLRP3 blockade reverses morphine-prolonged neuropathic pain and proinflammatory immune actions in prenatal alcohol-exposed male mice.Neuropharmacology · 2026Article
- Phenotypic Factors and Celecoxib Efficacy in Knee OA: A Post‑hoc Pooled Analysis of Two Randomized, Double‑Blind, Placebo‑Controlled Trials.Pain and therapy · 2026Article
- Association between resting-state alpha oscillations and postoperative pain following endodontic treatment.Odontology · 2026Article
- Sex Differences in the Effects of L-Menthol on Nociception in the Hot Plate Test and Acetic Acid Writhing Test in BALB/c Mice.Iranian journal of medical sciences · 2026Article
- Article
- The Role of Clinical Pharmacogenetics and Opioid Interactions in Pain Management: Current Evidence and Future Perspectives.Pharmaceutics · 2026Review
- Validity and reliability of the persian adapted version of the labor pain relief attitude questionnaire for pregnant women (P-LPRAQ-p).Journal of education and health promotion · 2026Article
- Analgesic efficacy in women and men with cancer pain, treated with strong opioids: are there differences?BMJ oncology · 2026Article
- Impact of Analgesic Modalities on Postoperative Breakthrough Pain Following Anterior Cruciate Ligament Reconstruction: A Retrospective Study.Journal of pain research · 2026Article
- Exploring salivary metabolites as biomarkers in chronic craniofacial and orofacial pain: a metabolomic analysis.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Sex-Related Anti-Nociceptive Activity of a Flavonoid-Based Formulated Extract from Citrus Peels (Gold Lotion): New Insights into a Rat Model.Foods (Basel, Switzerland) · 2025Article
- Burden of low-back pain disease caused by occupational ergonomic factors in China from 1990 to 2021 and forecast for 2035: a systematic analysis and comparison with global trends.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Genetic Variation and Sex-Based Differences: Current Considerations for Anesthetic Management.Current issues in molecular biology · 2025Review
- Efficacy of morphine versus fentanyl patient-controlled analgesia for postoperative pain management in colorectal surgery.Qatar medical journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Genetic variations and gender contribute significantly to the large interpatient variations in opioid-related serious adverse effects and differences in pain relief with other analgesics. Opioids are the most commonly used analgesics to relieve moderate-to-severe postoperative pain. Narrow therapeutic index and unexplained large interpatient variations in opioid-related serious adverse effects and analgesia negatively affect optimal perioperative outcomes. In surgical, experimental, chronic, and neuropathic pain models, females have been reported to have more pain than males. This review focuses on literature evidence of differences in pain relief due to multiple genetic variations and gender of the patient.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.