ArticleOncoTargets and therapy2018
The prognostic roles of mRNAs of the exosomes derived from bone marrow stromal cells in common malignancies: a bioinformatic study.
Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Zinc Finger 521 Modulates the Nrf2-Notch Signaling Pathway in Human Ovarian Carcinoma.International journal of molecular sciences · 2023Article
- Predicting the molecular mechanism-driven progression of breast cancer through comprehensive network pharmacology and molecular docking approach.Scientific reports · 2023Article
- Exosomal microRNA-551b-3p from bone marrow-derived mesenchymal stromal cells inhibits breast cancer progression via regulating TRIM31/Akt signaling.Human cell · 2022Article
- Enhanced ZNF521 expression induces an aggressive phenotype in human ovarian carcinoma cell lines.PloS one · 2022Article
- Immune-related gene expression signatures in colorectal cancer.Oncology letters · 2021Article
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Abstract
backgroundThe inclusion of exosomes enters the recipient cells by means of endocytosis or direct fusion for information exchange between cells and cells. The inclusion of BMSCs-exo helps to guide the diagnosis and prognosis of cancer, especially cancer. PURPOSE: This research was to systematically elucidate the prognostic value of mRNAs of the exosomes derived from bone marrow stromal cells (BMSCs) in common malignant neoplasms, such as breast cancer, ovarian cancer, lung cancer, and gastric cancer.
methodsGene expression data (GSE78235) for the exosomes derived from BMSCs were extracted from the Gene Expression Omnibus database. Firstly, the differentially expressed genes were detected by comparing the RNA expression from exosomes derived from BMSCs between four tumor patients and two healthy controls using the limma package. Subsequently, functional enrichment analysis, including Gene Ontology and Kyoto Encyclopedia of Genes and Genomes of differentially expressed genes, was performed using the Functional Enrichment analysis tool (FunRich v3.1.3) software followed by the construction of a protein-protein interaction (PPI) network via STRING v3.6.0. Molecular Complex Detection was used to screen the hub proteins by setting up the following threshold score ≥4 and nodes ≥10. Cytoscape v3.6.1 was used to for visualizing PPI network. Finally, Kaplan-Meier analysis for hub proteins was performed by Kaplan-Meier plotter online platform.
resultsA total of 386 genes originating from the exosomes derived from BMSCs were identifed as statistically signifcant (
conclusionTaken together, our findings revealed the prognostic roles of mRNAs of exosomes derived from BMSCs and provided implications for targeted therapy for common malignant neoplasms. However, further studies require large samples and experimental verification.
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