Evidence map›Paper›PMID 30519035›Full record

ArticleOncoTargets and therapy2018

MicroRNA-18a promotes hepatocellular carcinoma proliferation, migration, and invasion by targeting Bcl2L10.

Xiaodong Wang, Jian Lu, Jisen Cao, Bozhao Ma, Chao Gao, Feng Qi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in OncoTargets and therapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaodong WangDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, qifengtmu2017@163.com.
Jian LuDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, qifengtmu2017@163.com.
Jisen CaoDepartment of Hepatobiliary Surgery, Tianjin Third Center Hospital, Tianjin, China.
Bozhao MaDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, qifengtmu2017@163.com.
Chao GaoDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, qifengtmu2017@163.com.
Feng QiDepartment of General Surgery, Tianjin Medical University General Hospital, Tianjin, China, qifengtmu2017@163.com.
Tianjin Medical University General Hospital · CNTianjin Third Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is known to feature several microRNA dysregulations. This study aimed to determine and investigate the prognostic value of microRNA (miRNA/miR)-18a and its role in regulating the progression of HCC.

methodsmiR-18a expressions in human HCC tissues, pair-matched adjacent normal liver tissues as well as in HCC cell lines were determined by quantitative real-time PCR. The prognostic value of miR-18a was determined using Kaplan-Meier survival analysis and multivariable Cox regression assay. The ability of miR-18a in promoting HCC progression was verified in vitro.

resultsmiR-18a expressions in HCC tissues and cells were more than twice those of the normal control group (

conclusionmiR-18a may serve as a prognostic biomarker of HCC as it is demonstrated to carry out a decisive role in HCC progression by promoting HCC cell invasion, migration, and proliferation through targeting Bcl2L10.

Indexed as

apoptosisBcl2L10cell cyclehepatocellular carcinomamiR-18a

Identifiers

PMID30519035
PMCPMC6235330
OpenAlexW2899646829

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.