Evidence map›Paper›PMID 30519015›Full record

ArticleInternational journal of nanomedicine2018

Reinforcement of calcium phosphate cement using alkaline-treated silk fibroin.

Muli Hu, Zhiwei He, Fengxuan Han, Chen Shi, Pinghui Zhou, Feng Ling, Xuesong Zhu, Huilin Yang, Bin Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Muli HuDepartment of Polymer Science, College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, China.
Zhiwei HeDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China, binli@suda.edu.cn.
Fengxuan HanDepartment of Polymer Science, College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, China.
Chen ShiDepartment of Biomedical Engineering, National University of Singapore, Singapore, Singapore.
Pinghui ZhouDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China, binli@suda.edu.cn.
Feng LingDepartment of Polymer Science, College of Chemistry, Chemical Engineering and Materials Science, Orthopaedic Institute, Soochow University, Suzhou, China.
Xuesong ZhuDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China, binli@suda.edu.cn.
Huilin YangDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China, binli@suda.edu.cn.
Bin LiDepartment of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China, binli@suda.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBone cement plays an important role in the treatment of osteoporotic vertebral compression fractures. Calcium phosphate cement (CPC) is a potential alternative to poly(methyl methacrylate), currently the gold standard of bone cements. However, the poor mechanical properties of CPCs limit their clinical applications. The objective of this study was to develop reinforced CPCs for minimally invasive orthopedic surgeries by compositing silk fibroin (SF) with α-tricalcium phosphate.

methodsSF solution was treated with calcium hydroxide and characterized by Zeta potential analyzer and Fourier transform infrared spectroscopy. The alkaline-treated SF (tSF) was com-posited with α-tricalcium phosphate to obtain tSF/CPC composite, which was characterized using mechanical tests, scanning electron microscopy, handling property and biocompatibility tests, and sheep vertebral augmentation tests.

resultsUpon treatment with calcium hydroxide, larger SF particles and more abundant negative charge appeared in tSF solution. The tSF/CPCs exhibited a compact structure, which consisted of numerous SF -CPC clusters and needle-like hydroxyapatite (HAp) crystals. In addition, high transition rate of HAp in tSF/CPCs was achieved. As a result, the mechanical property of tSF/ CPC composite cements was enhanced remarkably, with the compressive strength reaching as high as 56.3±1.1 MPa. Moreover, the tSF/CPC cements showed good injectability, anti-washout property, and decent biocompatibility. The tSF/CPCs could be used to augment defected sheep vertebrae to restore their mechanical strength.

conclusiontSF/CPC may be a promising composite bone cement for minimally invasive orthopedic surgeries.

Indexed as

AlkaliesAnimalsBiocompatible MaterialsBombyxBone CementsCalcium PhosphatesCell LineCell ProliferationCompressive StrengthDynamic Light ScatteringFibroinsHydrogen-Ion ConcentrationMiceSheepSolutionsSpectroscopy, Fourier Transform InfraredAlkaliesBiocompatible MaterialsBone Cementscalcium phosphateCalcium PhosphatesFibroinsSolutionsbone cementcalcium hydroxidecalcium phosphatereinforcementsilk fibroin

Identifiers

PMID30519015
PMCPMC6233488

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.