ArticleJSLS : Journal of the Society of Laparoendoscopic Surgeons
The Length of Surgical Skin Incision in Postoperative Inflammatory Reaction.
Article in JSLS : Journal of the Society of Laparoendoscopic Surgeons. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
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- Article
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- Arthroscopy-assisted reduction for Jacob type II pediatric humeral lateral condyle fractures: a clinical efficacy study.Frontiers in pediatrics · 2025Article
- Small cuts, big questions: the impact of incision length in minimally invasive robotic cardiac surgery.Frontiers in cardiovascular medicine · 2025Article
- Review
- Probiotics in Postoperative Pain Management.Journal of personalized medicine · 2023Review
- Green Light Exposure Elicits Anti-inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-surgical Pain.The journal of pain · 2023Article
- A novel videoscope and tool kit for percutaneous pericardial access under direct visualization.Biomedical engineering online · 2023Article
- Minimally invasive treatment for glioblastoma through endoscopic surgery including tumor embolization when necessary: a technical note.Frontiers in neurology · 2023Article
- Sensor-Based Automated Detection of Electrosurgical Cautery States.Sensors (Basel, Switzerland) · 2022Article
- Analgesic effects of ultrasound-guided fourquadrant transversus abdominis plane in patients with cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a prospective, randomized, controlled study.Anesthesia and pain medicine · 2022Article
- Percutaneous ultrasound-guided ulnar nerve release technique compared to open technique: A cadaveric study.SICOT-J · 2022Article
- Comparison of Clinical Data Between Patients With Complications and Without Complications After Spinal Tuberculosis Surgery: A Propensity Score Matching Analysis.Frontiers in surgery · 2022Article
- Scarless Total Breast Reconstruction with a Fat-augmented Latissimus Dorsi Flap.Plastic and reconstructive surgery. Global open · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesSurgery provokes inflammatory and immune responses, so efforts have been made to reduce host response by using less invasive techniques. The purpose of this experimental study was to investigate the surgical stress induced by skin incision and the role of liver response in this process.
methodsSeventy male anesthetized Wistar rats were subjected to a midline incision confined strictly to the skin (dermis) of either 1 cm long (n = 20), 10 cm long (n = 20), or no incision (n = 20) or served as controls (n = 10). Skin trauma was left open for a 20-minutes period, and then was meticulously sutured. At 3 and 24 hours later, laparotomy was performed on half the rats of each group, for blood and liver sampling. In serum and liver homogenates, cytokine-induced neutrophil chemoattractant (CINC)1/interleukin (IL)-8 and tumor necrosis factor (TNF)-α levels were measured with enzyme-linked immunosorbent assays and nitric oxide (NO) using a Griess reaction.
resultsSkin trauma was found to significantly (
conclusionOur findings suggest that inflammatory and immune reactions induced by skin-only surgical trauma are closely correlated to the length of skin incision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.