Evidence map›Paper›PMID 30518958›Full record

ArticleScientific reports2018

The potential of substance P to initiate and perpetuate cortical spreading depression (CSD) in rat in vivo.

Frank Richter, Annett Eitner, Johannes Leuchtweis, Reinhard Bauer, Andrea Ebersberger, Alfred Lehmenkühler, Hans-Georg Schaible

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frank RichterInstitute of Physiology I/Neurophysiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany. Frank.Richter@med.uni-jena.de.
Annett EitnerInstitute of Physiology I/Neurophysiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Johannes LeuchtweisInstitute of Physiology I/Neurophysiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Reinhard BauerInstitute of Molecular Cell Biology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Andrea EbersbergerInstitute of Physiology I/Neurophysiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Alfred LehmenkühlerPain Institute and Center for Medical Education, Düsseldorf, Germany.
Hans-Georg SchaibleInstitute of Physiology I/Neurophysiology, Jena University Hospital - Friedrich Schiller University Jena, Jena, Germany.
Friedrich Schiller University Jena · DEJena University Hospital · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The tachykinin substance P (SP) increases neuronal excitability, participates in homeostatic control, but induces brain oedema after stroke or trauma. We asked whether SP is able to induce cortical spreading depression (CSD) which often aggravates stroke-induced pathology. In anesthetized rats we applied SP (10

Indexed as

Cortical Spreading DepressionAnimalsCerebral CortexMaleNeurokinin-1 Receptor AntagonistsNeurotransmitter AgentsRatsRats, WistarReceptors, Neurokinin-1Substance PNeurokinin-1 Receptor AntagonistsNeurotransmitter AgentsReceptors, Neurokinin-1Substance P

Identifiers

PMID30518958
PMCPMC6281573
OpenAlexW2902956720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.