ArticleScientific reports2018
HelixComplex snail mucus exhibits pro-survival, proliferative and pro-migration effects on mammalian fibroblasts.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 96 citations in OpenAlex.
- Integrating in vivo and in silico: a comprehensive study of Helix aspersa mucin's therapeutic properties.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Pharmacokinetics and residue depletion of enrofloxacin and its metabolite ciprofloxacin in land snailsJournal of veterinary research · 2026Article
- In-situ fabrication of a soluble PVP/ snail mucus-based fibrous facial mask via handheld electrospinning.Scientific reports · 2026Article
- Laboratory toxicological assessment of ozone exposure on terrestrial snail Theba pisana and its impact on histopathological alterations.Scientific reports · 2026Article
- Integrated morphological, molecular, histological, and antimicrobial analysis of the leather leaf slug Eleutherocaulis alte from Assiut Governorate, Egypt.Scientific reports · 2026Article
- Chemical Variability and Biological Potential ofMolecules (Basel, Switzerland) · 2025Review
- Unveiling the therapeutic journey of snail mucus in diabetic wound care.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Hydroxypropyl-Methylcellulose and GlicoProOphthalmology and therapy · 2025Article
- Synergistic Antibacterial Effect of Mucus Fraction fromAntibiotics (Basel, Switzerland) · 2025Article
- From Nature to Nurture: The Science and Applications of Snail Slime in Health and Beauty.Journal of cosmetic dermatology · 2025Review
- Green Synthesis of Antibacterial CuO Nanoparticles Based on the Synergy BetweenMolecules (Basel, Switzerland) · 2025Article
- Mucus-derived biomaterial dressings: a novel approach to accelerate wound healing.Theranostics · 2025Review
- Fabrication of BioactiveACS omega · 2024Article
- Influence of the extraction method on functional properties of commercial snail secretion filtrates.Scientific reports · 2024Article
- Article
- Biological Properties of the Mucus and Eggs ofInternational journal of molecular sciences · 2024Article
- Antibacterial Properties of Peptide and Protein Fractions fromMolecules (Basel, Switzerland) · 2024Article
- Development of CuO Nanoparticles from the Mucus of Garden SnailPharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- A Novel Ophthalmic Solution Containing GlicoproJournal of clinical medicine · 2024Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Snail mucus is a mixture of active substances commonly thought to have healthy properties for the treatment of skin disorders. Although snail mucus is an ingredient of several cosmetic and para-pharmaceutic products, a comprehensive characterization of chemical composition and biological effects is still missing. Crude purified extracts from Helix aspersa muller mucus (HelixComplex) were prepared and, after chemical characterization, tested on in vitro experimental models. Differently from what expected, HelixComplex was characterized by the presence of small amounts of glycolic acid and allantoin. By using different in vitro assays on fibroblast cultures, we found that HelixComplex lacked of cytotoxicity, protected cells from apoptosis (p < 0.05) and, importantly, was able to significantly induce cell proliferation and migration through direct and indirect mechanisms. These effects were associated to morphological changes, cytoskeleton re-organization and release of cytokines. In conclusion, our findings suggest that snail mucus biological effects are attributable to cell proliferation and migration, and pave the way for further investigating snail mucus potential as therapeutic agent.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.