ArticleNature2018
Consistent success in life-supporting porcine cardiac xenotransplantation.
Erratum issuedAbstract read
In one paragraph
Article in Nature, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 252 papers.
0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed
46.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
252 citing papers in PubMed, 502 citations in OpenAlex.
- First-in-Human, Phase 1, Randomized, Double-Blind, Placebo-Controlled Study of TNX-1500, an Fc-Modified anti-CD154 Monoclonal Antibody, Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Ascending Doses in Healthy Adults.Journal of clinical immunology · 2026Trial
- Review
- Beyond immune rejection: integrative genetic engineering strategies for overcoming coagulopathy in xenotransplantation.Clinical transplantation and research · 2026Review
- The xenotransplantation hybrid hospital: structural, economic, and regulatory frameworks for zero-ischemia clinical translation.Clinical transplantation and research · 2026Review
- Bibliometric analysis of liver xenotransplantation (2005-2025): trends, challenges and future directions.Updates in surgery · 2026Article
- Alterations in steroid hormone receptors, angiogenic, cell proliferation, apoptotic, and Ras-related factors during estrous cycle in porcine corpus luteum.Journal of animal science and technology · 2026Article
- Livestock immunogenomics based on omics integration: from infection and stress to xenotransplantation.Journal of animal science and technology · 2026Review
- Future of xenotransplantation in Korea.Clinical transplantation and research · 2026Review
- Porcine kidney xenotransplantation: From primate models to clinical reality.Animal models and experimental medicine · 2026Review
- Gene-edited pig cardiac xenotransplantation as a bridge to allotransplantation in infants: Progress in a pig-to-baboon model.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026Article
- Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents.Nature medicine · 2026Article
- From the Bench to the Bedside and Back: Contemporary Applications of Basic Science to Innovations in Heart Transplantation.The Canadian journal of cardiology · 2026Review
- Xenotransplantation: Promises and Perils.Annual review of medicine · 2026Review
- Cryopreservation Strategies to Improve Access to Organ Transplantation.Transplantation · 2026Review
- Modern xenotransplantation: rewiring glycan-mediated immunogenicity via genome-glycome convergence.EBioMedicine · 2026Review
- Review
- T cell-mediated immune responses in xenotransplantation: mechanisms and therapeutic strategies.Frontiers in immunology · 2026Review
- Effects of cooling on pig heart excitation and contraction.Frontiers in cardiovascular medicine · 2026Article
- New Perfusion and Preservation Strategies for Donor Hearts.European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes · 2026Review
- Optimizing Temperature in Ex Situ Heart Perfusion: A Comparative Review of Traditional and Novel Methods in Heart Transplantation.Journal of cardiovascular development and disease · 2026Review
192 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
50 authors at 8 institutions in 3 countries.
Matthias LänginDepartment of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Tanja MayrDepartment of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Bruno ReichartTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany. bruno.reichart@med.uni-muenchen.de.
Sebastian MichelDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Stefan BuchholzDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Sonja GuethoffTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Alexey DashkevichDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Andrea BaehrInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Stefanie EgererInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Andreas BauerDepartment of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Maks MihaljDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Alessandro PanelliTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Lara IsslTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Jiawei YingTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Ann Kathrin FreschTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Ines ButtgereitTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Maren MokelkeTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Julia RadanTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Fabian WernerDepartment of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Isabelle LutzmannTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Stig SteenDepartment of Cardiothoracic Surgery, Lund University and Skåne University Hospital, Lund, Sweden.
Trygve SjöbergDepartment of Cardiothoracic Surgery, Lund University and Skåne University Hospital, Lund, Sweden.
Audrius PaskeviciusDepartment of Cardiothoracic Surgery, Lund University and Skåne University Hospital, Lund, Sweden.
Liao QiumingDepartment of Cardiothoracic Surgery, Lund University and Skåne University Hospital, Lund, Sweden.
Riccardo SfrisoDepartment for BioMedical Research (DMBR), University of Bern, Bern, Switzerland.
Robert RiebenDepartment for BioMedical Research (DMBR), University of Bern, Bern, Switzerland.
Maik DahlhoffInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Barbara KesslerInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Elisabeth KemterInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Mayuko KuromeInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Valeri ZakhartchenkoInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Katharina KlettI. Medizinische Klinik, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Rabea HinkelI. Medizinische Klinik, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Christian KupattI. Medizinische Klinik, Klinikum Rechts der Isar, Technical University of Munich, Munich, Germany.
Almuth FalkenauInstitute of Veterinary Pathology, LMU Munich, Munich, Germany.
Simone ReuInstitute of Pathology, Medical Faculty, LMU Munich, Munich, Germany.
Reinhard EllgassDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Rudolf HerzogDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Uli BinderXL-protein GmbH, Freising, Germany.
Günter WichWacker-Chemie AG, Munich, Germany.
Arne SkerraMunich Center for Integrated Protein Science (CIPS-M) and Lehrstuhl für Biologische Chemie, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
David AyaresRevivicor, Blacksburg, VA, USA.
Alexander KindChair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technical University of Munich, Munich, Germany.
Uwe SchönmannGerman Primate Centre, Göttingen, Germany.
Franz-Josef KaupGerman Primate Centre, Göttingen, Germany.
Christian HaglDepartment of Cardiac Surgery, University Hospital, LMU Munich, Munich, Germany.
Eckhard WolfInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Nikolai KlymiukInstitute of Molecular Animal Breeding and Biotechnology, Gene Center, LMU Munich, Munich, Germany.
Paolo BrennerTransregional Collaborative Research Center 127, Walter Brendel Centre of Experimental Medicine, LMU Munich, Munich, Germany.
Jan-Michael AbichtDepartment of Anaesthesiology, University Hospital, LMU Munich, Munich, Germany.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DESkåne University Hospital · SETechnical University of Munich · DEGerman Primate Center · DEUniversity of Bern · CHInstitute for Sports Medicine · DEWacker Group (Germany) · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply of allogeneic donor organs falls far short of the clinical need
Indexed as
Heart TransplantationPapioSwineTransplantation, HeterologousAnimalsAntibodiesComplement System ProteinsEnzymesFibrinGalactosyltransferasesHeterograftsHumansLiverMaleMembrane Cofactor ProteinMyocardiumalpha-1,3-galactosyltransferase 1, porcineAntibodiesComplement System ProteinsEnzymesFibrinGalactosyltransferasesMembrane Cofactor ProteinThrombomodulin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.