Evidence map›Paper›PMID 30518849›Full record

ArticleNature structural & molecular biology2018

Structure of a functional obligate complex III

Benjamin Wiseman, Ram Gopal Nitharwal, Olga Fedotovskaya, Jacob Schäfer, Hui Guo, Qie Kuang, Samir Benlekbir, Dan Sjöstrand, Pia Ädelroth, John L Rubinstein and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature structural & molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 137 citations in OpenAlex.

  1. Article
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  5. TheProceedings of the National Academy of Sciences of the United States of America · 2026
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  6. Article
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  8. Future Research Directions on Mycobacterium tuberculosis Proteins.Advances in experimental medicine and biology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. ATP synthesis driven by atmospheric hydrogen concentrations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Article
  15. Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Article
  17. Inhibition mechanism of potential antituberculosis compound lansoprazole sulfide.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Review
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Benjamin Wiseman *Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-2994-5839
Ram Gopal Nitharwal *Department of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Olga FedotovskayaDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Jacob SchäferDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Hui GuoHospital for Sick Children, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0001-7007-2876
Qie KuangDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Samir BenlekbirHospital for Sick Children, Toronto, Ontario, Canada.
Dan SjöstrandDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Pia ÄdelrothDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
John L RubinsteinHospital for Sick Children, Toronto, Ontario, Canada. john.rubinstein@utoronto.ca.ORCID http://orcid.org/0000-0003-0566-2209
Peter BrzezinskiDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. peterb@dbb.su.se.ORCID http://orcid.org/0000-0003-3860-4988
Martin HögbomDepartment of Biochemistry and Biophysics, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. hogbom@dbb.su.se.ORCID http://orcid.org/0000-0001-5574-9383
Stockholm University · SEUniversity of Toronto · CAHospital for Sick Children · CA

Funding

CIHR
6 · The paper itself

Abstract

In the mycobacterial electron-transport chain, respiratory complex III passes electrons from menaquinol to complex IV, which in turn reduces oxygen, the terminal acceptor. Electron transfer is coupled to transmembrane proton translocation, thus establishing the electrochemical proton gradient that drives ATP synthesis. We isolated, biochemically characterized, and determined the structure of the obligate III

Indexed as

Models, MolecularCell RespirationCryoelectron MicroscopyElectron TransportElectron Transport Chain Complex ProteinsElectron Transport Complex IIIMycobacterium smegmatisOxidation-ReductionOxygenProtein Structure, TertiaryElectron Transport Chain Complex ProteinsElectron Transport Complex IIIOxygen

Identifiers

PMID30518849
OpenAlexW2902898494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.