Evidence map›Paper›PMID 30518825›Full record

ArticleInternational journal of obesity (2005)2019

Effects of bariatric surgery on retinal microvascular architecture in obese patients.

Antti Viljanen, Minna Soinio, Carol Yim-Lui Cheung, Jarna C Hannukainen, Henry K Karlsson, Tien Yin Wong, Alun D Hughes, Paulina Salminen, Pirjo Nuutila, Eija Vesti and 1 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Antti ViljanenMedilaser Turku, Cor Group, Turku, Finland.
Minna SoinioDepartment of Endocrinology, Turku University Hospital, Turku, Finland.
Carol Yim-Lui CheungDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Ma Liu Shui, Hong Kong.
Jarna C HannukainenTurku PET Centre, University of Turku, Turku, Finland.
Henry K KarlssonTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Alun D HughesInstitute of Cardiovascular Science, University College London, London, UK.
Paulina SalminenDepartment of Surgery, University of Turku, and Turku University Hospital, Turku, Finland.
Pirjo NuutilaTurku PET Centre, University of Turku and Turku University Hospital, Turku, Finland.
Eija VestiDepartment of Ophthalmology, University of Turku and Turku University Hospital, Turku, Finland.
Robyn J TappPopulation Health Research Institute, St Georges, University of London, London, UK. rtapp@sgul.ac.uk.ORCID http://orcid.org/0000-0002-8553-2684
University of Turku · FIChinese University of Hong Kong · HKNational University of Singapore · SGThe University of Melbourne · AUTurku University Hospital · FIUniversity College London · GB

Funding

British Heart Foundation CS/13/1/30327
6 · The paper itself

Abstract

STUDY

aimRetinal microvasculature changes reflect systemic small vessel damage from obesity. The impact of bariatric surgery induced weight loss on the microvasculature is relatively unknown. We hypothesized that weight loss following bariatric surgery would be associated with improved structural changes in the retinal microvasculature, reflecting an overall improvement in microvascular health.

methodsThe study included 22 obese subjects scheduled for bariatric surgery (laparoscopic Roux-en-Y gastric bypass or a sleeve gastrectomy) and 15 lean, age-matched controls. Ophthalmic examination, including fundus photography, was performed at baseline and 6-months. Retinal microvasculature caliber was analysed quantitatively using a semi-automated computer program and summarized as central retinal artery equivalent (CRAE) and venular equivalent (CRVE).

resultsMean weight loss at 6 months was 26.1 kg ± 8 kg in the bariatric surgery group. Retinal artery caliber increased (136.0 ± 1.4 to 141.4 ± 1.4 µm, p = 0.013) and venular caliber decreased (202.9 ± 1.9 to 197.3 ± 1.9 µm, p = 0.046) in the bariatric surgery group by 6 months, with no change in arteriolar (136.6 ± 1.1 to 134.5 ± 1.2, p = 0.222) or venular (195.1 ± 2.1 to 193.3 ± 2.2, p = 0.550) caliber in the control group. The arteriolar to venular ratio increased in the bariatric surgery group, with no change in the control group at 6 months.

conclusionsThe findings suggest obesity-related microvascular changes are reversible after bariatric surgery-induced weight loss. The capacity for the retinal microvasculature to improve following bariatric surgery suggests plasticity of the human microvasculature early in the disease course.

Indexed as

Obesity, MorbidAdultBariatric SurgeryFemaleHumansMicrovesselsMiddle AgedProspective StudiesRetinal VesselsTreatment OutcomeWeight Loss

Identifiers

PMID30518825
OpenAlexW2902261494

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.