ArticleJournal of perinatology : official journal of the California Perinatal Association2019
Histological chorioamnionitis and developmental outcomes in very preterm infants.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- Immune Impairment in Preterm Neonates and Its Impact on Morbidity.Indian journal of pediatrics · 2026Review
- Histologic Chorioamnionitis and Neurodevelopment in Preterm Infants.JAMA network open · 2025Article
- The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review.European journal of pediatrics · 2024Review
- Trophoblast inclusions and adverse birth outcomes.PloS one · 2022Article
- A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever.PeerJ · 2022Article
- Elevated neutrophil-lymphocyte ratios in extremely preterm neonates with histologic chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Exosomal delivery of NF-κB inhibitor delays LPS-induced preterm birth and modulates fetal immune cell profile in mouse models.Science advances · 2021Article
- Microbial invasion of the amniotic cavity is associated with impaired cognitive and motor function at school age in preterm children.Pediatric research · 2020Article
- Maternal-Fetal Inflammation in the Placenta and the Developmental Origins of Health and Disease.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize the association of histological chorioamnionitis (HCA) with neurodevelopmental outcomes in children born at <30 weeks gestation. STUDY
designThis retrospective cohort study included infants born 2006-2012 in whom placental histopathology, neonatal outcomes, and Bayley-III assessment at age 2 years were available. We assessed the association of HCA exposure with cognitive, language, and motor delay with logistic regression models adjusted for gestational age, sex, small for gestational age and brain injury.
resultsOf 1353 infants, 985 had histological and neonatal data available, and 708 infants had Bayley-III assessments. HCA-exposed infants were at higher risk of some neonatal adverse outcomes, and stage of HCA correlated with low Apgar score and early-onset sepsis. Exposure to HCA was not associated with neurodevelopmental outcomes in adjusted models including stage of HCA.
conclusionsExposure to HCA, especially higher stage, was associated with neonatal morbidity but not with adverse neurodevelopmental outcomes at 2 years of age.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.