ArticleNature communications2018
Chromatin interactions and expression quantitative trait loci reveal genetic drivers of multimorbidities.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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Who cites it
41 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Establishing gene regulatory networks from Parkinson's disease risk loci.Brain : a journal of neurology · 2022Pooled it
- Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study.PLoS genetics · 2025Article
- Unraveling ADHD: genes, co-occurring traits, and developmental dynamics.Life science alliance · 2025Article
- Chrombus-XMBD: a graph convolution model predicting 3D-genome from chromatin features.Briefings in bioinformatics · 2025Article
- The influence ofFrontiers in nutrition · 2025Article
- Observational
- Links between melanoma germline risk loci, driver genes and comorbidities: insight from a tissue-specific multi-omic analysis.Molecular oncology · 2024Article
- Identification of 27 allele-specific regulatory variants in Parkinson's disease using a massively parallel reporter assay.NPJ Parkinson's disease · 2024Article
- Discovering genetic mechanisms underlying the co-occurrence of Parkinson's disease and non-motor traits.NPJ Parkinson's disease · 2024Article
- Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.Frontiers in immunology · 2024Article
- De novo network analysis reveals autism causal genes and developmental links to co-occurring traits.Life science alliance · 2023Article
- Genome-wide association studies and fine-mapping identify genomic loci for n-3 and n-6 polyunsaturated fatty acids in Hispanic American and African American cohorts.Communications biology · 2023Article
- Spatially constrained gene regulation identifies key genetic contributions of preeclampsia, hypertension, and proteinuria†.Biology of reproduction · 2023Article
- De novo discovery of traits co-occurring with chronic obstructive pulmonary disease.Life science alliance · 2023Article
- Genome-Wide Association Studies and fine-mapping of genomic loci for n-3 and n-6 Polyunsaturated Fatty Acids in Hispanic American and African American Cohorts.Research square · 2023Article
- Impact ofFrontiers in nutrition · 2023Article
- Article
- Interpretation of the role of germline and somatic non-coding mutations in cancer: expression and chromatin conformation informed analysis.Clinical epigenetics · 2022Review
- Local genetic covariance between serum urate and kidney function estimated with Bayesian multitrait models.G3 (Bethesda, Md.) · 2022Article
- Genetic variation as a long-distance modulator of RAD21 expression in humans.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical studies of non-communicable diseases identify multimorbidities that suggest a common set of predisposing factors. Despite the fact that humans have ~24,000 genes, we do not understand the genetic pathways that contribute to the development of multimorbid non-communicable disease. Here we create a multimorbidity atlas of traits based on pleiotropy of spatially regulated genes. Using chromatin interaction and expression Quantitative Trait Loci (eQTL) data, we analyse 20,782 variants (p < 5 × 10
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