Evidence map›Paper›PMID 30518610›Full record

ArticleScience translational medicine2018

Noninvasive

Elizabeth W Tucker, Beatriz Guglieri-Lopez, Alvaro A Ordonez, Brittaney Ritchie, Mariah H Klunk, Richa Sharma, Yong S Chang, Julian Sanchez-Bautista, Sarah Frey, Martin A Lodge and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 3 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 3 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. A clinical practice guideline for tuberculous meningitis.The Lancet. Infectious diseases · 2026
    Guideline
  2. Model-Based Meta-analysis of Rifampicin Exposure and Mortality in Indonesian Tuberculous Meningitis Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020
    Pooled it
  3. Treatment of Drug-Resistant Tuberculosis. An Official ATS/CDC/ERS/IDSA Clinical Practice Guideline.American journal of respiratory and critical care medicine · 2019
    Guideline
  4. Trial
  5. Trial
  6. Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Trial
  7. Article
  8. Article
  9. Radiolabeled Antimicrobials for Infection Imaging: A Scoping Review.International journal of molecular sciences · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Automated radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2025
    Article
  14. Improved Radiosynthesis of [ACS infectious diseases · 2025
    Article
  15. Article
  16. Article
  17. Observational
  18. Article
  19. Review
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 1 country.

Elizabeth W TuckerCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-0971-3635
Beatriz Guglieri-LopezCenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.ORCID 0000-0001-7153-1894
Alvaro A OrdonezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-8571-0655
Brittaney RitchieCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Mariah H KlunkCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Richa SharmaCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Yong S ChangCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-4735-1302
Julian Sanchez-BautistaCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sarah FreyCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Martin A LodgeDivision of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Steven P RoweDivision of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Daniel P HoltDivision of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Jogarao V S GobburuCenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA.
Charles A PeloquinInfectious Disease Pharmacokinetics Laboratory, Pharmacotherapy and Translational Research, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.
William B MathewsDivision of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0001-8001-416X
Robert F DannalsDivision of Nuclear Medicine and Molecular Imaging, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-5483-5914
Carlos A PardoDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0002-4128-5335
Sujatha KannanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Vijay D IvaturiCenter for Translational Medicine, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA. vivaturi@rx.umaryland.edu sjain5@jhmi.edu.ORCID 0000-0002-6433-1154
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. vivaturi@rx.umaryland.edu sjain5@jhmi.edu.ORCID 0000-0001-9620-7070
Johns Hopkins University · USUniversity of Maryland, Baltimore · USAmerican Association of Colleges of Pharmacy · US

Funding

Pediatric Critical Care Scientist Development ProgramK12HD047349 · NICHD · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI HEATHER T. KEENAN, Kevin M Watt · 2004 to 2026
$17.0M
Novel Imaging Tracers for Rapid and Noninvasive Assessment of Bacterial InfectionR01EB020539 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2014 to 2018
$3.6M
Molecular Imaging for Pulmonary Infections and InflammationR01HL131829 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI JAIN, SANJAY · 2016 to 2018
$2.2M
Mechanisms and novel therapy in intrauterine inflammation induced brain injuryR01HD069562 · NICHD · JOHNS HOPKINS UNIVERSITY · PI KANNAN, SUJATHA · 2012 to 2016
$1.6M
NHLBI NIH HHS R01 HL131829NIBIB NIH HHS R01 EB020539NICHD NIH HHS K12 HD047349NICHD NIH HHS R01 HD069562
6 · The paper itself

Abstract

Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize TBM treatments. Current methods to measure intralesional drug distribution rely on tissue resection, which is difficult in humans and generally limited to a single time point even in animals. In this study, we developed a multidrug treatment model in rabbits with experimentally induced TBM and performed serial noninvasive dynamic

Indexed as

Positron-Emission TomographyAnimalsAntitubercular AgentsBrainCarbon RadioisotopesDose-Response Relationship, DrugFemaleHumansMaleProbabilityRabbitsRifampinTime FactorsTissue DistributionTuberculosis, MeningealAntitubercular AgentsCarbon-11Carbon RadioisotopesRifampin

Identifiers

PMID30518610
PMCPMC6360528
OpenAlexW2903100299

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.