Evidence map›Paper›PMID 30518389›Full record

ReviewReproductive biology and endocrinology : RB&E2018

Recurrent Implantation Failure-update overview on etiology, diagnosis, treatment and future directions.

Asher Bashiri, Katherine Ida Halper, Raoul Orvieto

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Reproductive biology and endocrinology : RB&E, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998279 (Intrauterine Infusion of Granulocyte Colony Stimulating Factor and Reproductive Outcomes in Infertile Women with History of Recurrent Implantation Failure), which is not on this map. Cited by 292 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
292citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998279 completednot on this mapstarted 2019, after this paper: background citation

Intrauterine Infusion of Granulocyte Colony Stimulating Factor and Reproductive Outcomes in Infertile Women with History of Recurrent Implantation Failure

TypeobservationalSponsorCairo UniversityRan2019 to 2024Enrolled100ConditionsRecurrent Implantation Failure, Granulocyte Colony-Stimulating Factor, InfertilityArmsGranulocyte Colony-Stimulating Factor, placebo
3 · Its place in the literature

Who cites it

292 citing papers in PubMed, 13 syntheses or guidelines pooled it.

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  7. Immunosuppressants in women with repeated implantation failure in assisted reproductive techniques: a systematic review and meta-analysis.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2024
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232 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Asher BashiriRecurrent Pregnancy Loss Clinic, Maternal-Fetal Medicine, and Ultrasound, Soroka University Medical Center, P.O.B. 151, 84101, Beer Sheva, Israel.
Katherine Ida HalperFaculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 151, 84101, Beer Sheva, Israel. khalps1@gmail.com.ORCID http://orcid.org/0000-0001-9766-8370
Raoul OrvietoDepartment of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel-Hashomer, 52621, Ramat Gan, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recurrent implantation failure (RIF) refers to cases in which women have had three failed in vitro fertilization (IVF) attempts with good quality embryos. The definition should also take advanced maternal age and embryo stage into consideration. The failure of embryo implantation can be a consequence of uterine, male, or embryo factors, or the specific type of IVF protocol. These cases should be investigated to determine the most likely etiologies of the condition, as this is a complex problem with several variables. There are multiple risk factors for recurrent implantation failure including advanced maternal age, smoking status of both parents, elevated body mass index, and stress levels. Immunological factors such as cytokine levels and presence of specific autoantibodies should be examined, as well as any infectious organisms in the uterus leading to chronic endometritis. Uterine pathologies such as polyps and myomas as well as congenital anatomical anomalies should be ruled out. Sperm analysis, pre-implantation genetic screening and endometrial receptivity should be considered and evaluated, and IVF protocols should be tailored to specific patients or patient populations. Treatment approaches should be directed toward individual patient cases. In addition, we suggest considering a new initial step in approach to patients with RIF, individualized planned activities to activate the brain's reward system in attempt to improve immunological balance in the body.

Indexed as

Embryo ImplantationEmbryo TransferEndometritisFemaleFertilization in VitroHumansInfertility, FemalePreimplantation DiagnosisRecurrenceRisk FactorsTreatment FailureChronic endometritisEndometrial scratchingIVIGLow molecular weight heparinPreimplantation Genetic Screening- PGSProgesteroneRecurrent implantation failure-RIFReward system

Identifiers

PMID30518389
PMCPMC6282265

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.