Evidence map›Paper›PMID 30518163›Full record

ArticleGenes2018

Population Genomic Analysis of North American Eastern Wolves (Canis lycaon) Supports Their Conservation Priority Status.

Elizabeth Heppenheimer, Ryan J Harrigan, Linda Y Rutledge, Klaus-Peter Koepfli, Alexandra L DeCandia, Kristin E Brzeski, John F Benson, Tyler Wheeldon, Brent R Patterson, Roland Kays and 2 more

Open access · goldAbstract read
In one paragraph

Article in Genes, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Elizabeth HeppenheimerDepartment of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. eh7@princeton.edu.ORCID 0000-0002-9164-3436
Ryan J HarriganCenter for Tropical Research, Institute of the Environment and Sustainability, University of California, Los Angeles, CA 90095, USA. iluvsa@ucla.edu.
Linda Y RutledgeDepartment of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. lrutledge@trentu.ca.ORCID 0000-0002-6008-2322
Klaus-Peter KoepfliCenter for Species Survival, Smithsonian Conservation Biology Institute, National Zoological Park, Washington, DC 20008, USA. klauspeter.koepfli527@gmail.com.
Alexandra L DeCandiaDepartment of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. klauspeter.koepfli527@gmail.com.
Kristin E BrzeskiDepartment of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. kbrzeski@mtu.edu.
John F BensonSchool of Natural Resources, University of Nebraska, Lincoln, NE 68583, USA. jbenson22@unl.edu.
Tyler WheeldonEnvironmental & Life Sciences, Trent University, Peterborough, ON K9L 0G2, Canada. tyler.wheeldon@ontario.ca.
Brent R PattersonEnvironmental & Life Sciences, Trent University, Peterborough, ON K9L 0G2, Canada. brent.patterson@ontario.ca.
Roland KaysNorth Carolina Museum of Natural Sciences and Department of Forestry and Environmental Resources, North Carolina State University, Raleigh, NC 27601, USA. rwkays@ncsu.edu.
Paul A HohenloheDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA. hohenlohe@uidaho.edu.
Bridgett M von HoldtDepartment of Ecology & Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA. vonholdt@princeton.edu.
Princeton University · USMinistry of Natural Resources and Forestry · CAMichigan Technological University · USNorth Carolina Museum of Natural Sciences · USSt Petersburg University · RUUniversity of California, Los Angeles · USUniversity of Idaho · USUniversity of Nebraska–Lincoln · US

Funding

National Science Foundation DGE1656466National Science Foundation PD-08-1269
6 · The paper itself

Abstract

The threatened eastern wolf is found predominantly in protected areas of central Ontario and has an evolutionary history obscured by interbreeding with coyotes and gray wolves, which challenges its conservation status and subsequent management. Here, we used a population genomics approach to uncover spatial patterns of variation in 281 canids in central Ontario and the Great Lakes region. This represents the first genome-wide single nucleotide polymorphism (SNP) dataset with substantial sample sizes of representative populations. Although they comprise their own genetic cluster, we found evidence of eastern wolf dispersal outside of the boundaries of protected areas, in that the frequency of eastern wolf genetic variation decreases with increasing distance from provincial parks. We detected eastern wolf alleles in admixed coyotes along the northeastern regions of Lake Huron and Lake Ontario. Our analyses confirm the unique genomic composition of eastern wolves, which are mostly restricted to small fragmented patches of protected habitat in central Ontario. We hope this work will encourage an innovative discussion regarding a plan for managed introgression, which could conserve eastern wolf genetic material in any genome regardless of their potential mosaic ancestry composition and the habitats that promote them.

Indexed as

canineconservation genomicsgeographic isolationrestriction-site associated DNAspatial structure

Identifiers

PMID30518163
PMCPMC6316216
OpenAlexW2902190495

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.