Evidence map›Paper›PMID 30518122›Full record

SynthesisNutrients2018

Effects of Protein Supplementation Combined with Exercise Intervention on Frailty Indices, Body Composition, and Physical Function in Frail Older Adults.

Chun-De Liao, Pi-Hsia Lee, Dun-Jen Hsiao, Shih-Wei Huang, Jau-Yih Tsauo, Hung-Chou Chen, Tsan-Hon Liou

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06096467 (The Impact of Cross-disciplinary Teamwork Care Model and Exercise Intervention on Physical Function Falls, and Physical Restraint for Residents in Long-term Care Institution), which is not on this map. Cited by 41 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 11 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06096467 nacompletednot on this mapstarted 2020, after this paper: background citation

The Impact of Cross-disciplinary Teamwork Care Model and Exercise Intervention on Physical Function Falls, and Physical Restraint for Residents in Long-term Care Institution

TypeinterventionalSponsorCardinal Tien HospitalRan2020 to 2024Enrolled22ConditionsExercise Intervention, Protein SupplementationArmsComprehension Exercise Training, Placebo milk, Protein Supplement
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 11 syntheses or guidelines pooled it, 89 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Chun-De LiaoSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. 08415@s.tmu.edu.tw.ORCID 0000-0002-1930-4915
Pi-Hsia LeeSchool of Nursing, College of Nursing, Taipei Medical University, Taipei 10675, Taiwan. pihsia@tmu.edu.tw.
Dun-Jen HsiaoSchool and Graduate Institute of Nutrition Science, College of Medicine, Taipei Medical University, Taipei 23561, Taiwan. antifat53@gmail.com.
Shih-Wei HuangDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei 23561, Taiwan. 13001@s.tmu.edu.tw.ORCID 0000-0003-1815-6938
Jau-Yih TsauoSchool and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Taipei 10055, Taiwan. jytsauo@ntu.edu.tw.
Hung-Chou ChenDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei 23561, Taiwan. 10462@s.tmu.edu.tw.
Tsan-Hon LiouDepartment of Physical Medicine and Rehabilitation, Shuang Ho Hospital, Taipei Medical University, Taipei 23561, Taiwan. peter_liou@s.tmu.edu.tw.ORCID 0000-0002-0959-4023
National Taiwan University · TWTaipei Medical University · TWTaipei Medical University-Shuang Ho Hospital · TWWan Fang Hospital · TW

Funding

Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, Taiwan W106HCP-14Taipei Medical University-Wan Fang Hospital, Taiwan 98TMU-WFH-05-3
6 · The paper itself

Abstract

Aging poses a high risk of lean mass loss, which can be effectively improved through resistance exercise training (RET), or multicomponent exercise training (MET) as well as nutrition supplementation, such as protein supplementation (PS). This study investigated the effects of PS plus exercise training on frail older individuals. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) that reported the efficacy of PS combined with RET or MET in frail older individuals. The included RCTs were analyzed through a meta-analysis and risk-of-bias assessment. We finally included 22 RCTs in the meta-analysis, with a mean (range/total) Physiotherapy Evidence Database score of 6.7 (4⁻9/10). PS plus exercise training significantly improved the frailty status (odds ratio = 2.77; p = 0.006), lean mass (standard mean difference (SMD) = 0.52;

Indexed as

Body CompositionDietary ProteinsDietary SupplementsExercise TherapyFrail ElderlyAgedAged, 80 and overFemaleHumansMaleRandomized Controlled Trials as TopicDietary Proteinsexercise trainingfrailtylean body massphysical functionprotein supplementation

Identifiers

PMID30518122
PMCPMC6315527
OpenAlexW2903362072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.