Evidence map›Paper›PMID 30518088›Full record

ArticleCancers2018

Glycodelin as a Serum and Tissue Biomarker for Metastatic and Advanced NSCLC.

Marc A Schneider, Thomas Muley, Rebecca Weber, Sabine Wessels, Michael Thomas, Felix J F Herth, Nicolas C Kahn, Ralf Eberhardt, Hauke Winter, Gudula Heussel and 3 more

Abstract read
In one paragraph

Article in Cancers, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Identification of prognostic immune genes in laryngeal cancer.The Journal of international medical research · 2020
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Marc A SchneiderTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany. marc.schneider@med.uni-heidelberg.de.ORCID 0000-0001-8269-3821
Thomas MuleyTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany. thomas.muley@med.uni-heidelberg.de.ORCID 0000-0002-8141-0604
Rebecca WeberTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany. rebecca.weber@med.uni-heidelberg.de.
Sabine WesselsTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. sabine.wessels@med.uni-heidelberg.de.
Michael ThomasTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. michael.thomas@med.uni-heidelberg.de.
Felix J F HerthTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. felix.herth@med.uni-heidelberg.de.
Nicolas C KahnTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. nicolas.kahn@med.uni-heidelberg.de.
Ralf EberhardtTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. ralf.eberhardt@med.uni-heidelberg.de.
Hauke WinterTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. hauke.winter@med.uni-heidelberg.de.
Gudula HeusselTranslational Lung Research Center Heidelberg (TLRC), Member of the German Center for Lung Research (DZL), D-69120 Heidelberg, Germany. gudula.heussel@med.uni-heidelberg.de.
Arne WarthInstitute of Pathology, University Hospital Heidelberg, D-69120 Heidelberg, Germany. warth@patho-uegp.de.
Christel Herold-MendeDivision of Experimental Neurosurgery, Heidelberg University Hospital, D-69120 Heidelberg, Germany. Christel.herold-mende@med.uni-heidelberg.de.
Michael MeisterTranslational Research Unit, Thoraxklinik at University Hospital Heidelberg, D-69126 Heidelberg, Germany. michael.meister@med.uni-heidelberg.de.

Funding

Deutsche Zentrum für Lungenforschung 82DZL00402
6 · The paper itself

Abstract

A major part of non-small cell lung cancer (NSCLC) patients treated with mono- or multimodal concept develop therapy resistance. Despite the abundance of biomarkers investigated in the past, there is still a need for valid NSCLC biomarkers. Glycodelin, an immunosuppressive endometrial protein, has been shown to be also expressed in NSCLC. Here, we investigated its potential as a biomarker in metastatic and advanced stage NSCLC. Glycodelin gene and protein expression were measured in 28 therapy-naïve resected tumors as well as in corresponding brain (

Indexed as

early detectionfollow-up biomarkerglycodelinNSCLCPAEP

Identifiers

PMID30518088
PMCPMC6315759

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.