Parasitic Behavior of Leukemic Cells in Systemic Host Metabolism.

Julie Leca, Thorsten Berger, Tak Wah Mak

Abstract readComment

In one paragraph

Article in Cell metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it

0cells of the map it votes in

2citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

Dysregulation of R-loop homeostasis shapes the immunosuppressive microenvironment and induces malignant progression in melanoma.Apoptosis : an international journal on programmed cell death · 2025
Article
Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival.International journal of molecular sciences · 2019
Review

4 · The record

Corrections and comments

Comment on
Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.2018

5 · Who and what money

Authors and funding

3 authors.

Julie LecaThe Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada.

Thorsten BergerThe Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada.

Tak Wah MakThe Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Departments of Medical Biophysics and Immunology, University of Toronto, Toronto, ON, Canada; The University of Hong Kong, Hong Kong. Electronic address: tmak@uhnresearch.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic reprogramming is a hallmark of cancer cell metabolism. Recently, in Cancer Cell, Ye and colleagues (2018) reported that leukemic cells have the capacity to modulate glucose metabolism in multiple organs of their host, thereby increasing the glucose resources available for malignant cell growth.

Indexed as

LeukemiaNeoplasmsCarbohydrate MetabolismCell Transformation, NeoplasticGlucoseHumansGlucose

Identifiers

PMID30517895

DOI10.1016/j.cmet.2018.11.011

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.