Evidence map›Paper›PMID 30517863›Full record

ArticleCell reports2018

HDAC3 Regulates the Transition to the Homeostatic Myelinating Schwann Cell State.

Laura H Rosenberg, Anne-Laure Cattin, Xavier Fontana, Elizabeth Harford-Wright, Jemima J Burden, Ian J White, Jacob G Smith, Ilaria Napoli, Victor Quereda, Cristina Policarpi and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Schwann Cell Development and Myelination.Cold Spring Harbor perspectives in biology · 2024
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Histone deacetylase-3: Friend and foe of the brain.Experimental biology and medicine (Maywood, N.J.) · 2020
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 2 countries.

Laura H RosenbergMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; CRUK Therapeutic Discovery Laboratories, Babraham Research Campus, Cambridge CB22 3AT, UK.
Anne-Laure CattinMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Xavier FontanaMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Elizabeth Harford-WrightMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Jemima J BurdenMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Ian J WhiteMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Jacob G SmithMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Ilaria NapoliMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Victor QueredaMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; The Scripps Research Institute, 130 Scripps Way, Jupiter, FL 33458, USA.
Cristina PolicarpiMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Jamie FreemanMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; Horizon Discovery, 8100 Cambridge Research Park, Cambridge CB25 9TL, UK.
Robin KettelerMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Antonella RiccioMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK.
Alison C LloydMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London WC1E 6BT, UK; UCL Cancer Institute, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: alison.lloyd@ucl.ac.uk.
MRC Laboratory for Molecular Cell Biology · GBScripps Research Institute · US

Funding

Cancer Research UK 11244Cancer Research UK 17135Cancer Research UK C378/A4308Medical Research Council MC_EX_G0800785Medical Research Council MR/N009169/1Medical Research Council MR/R023816/1
6 · The paper itself

Abstract

The formation of myelinating Schwann cells (mSCs) involves the remarkable biogenic process, which rapidly generates the myelin sheath. Once formed, the mSC transitions to a stable homeostatic state, with loss of this stability associated with neuropathies. The histone deacetylases histone deacetylase 1 (HDAC1) and HDAC2 are required for the myelination transcriptional program. Here, we show a distinct role for HDAC3, in that, while dispensable for the formation of mSCs, it is essential for the stability of the myelin sheath once formed-with loss resulting in progressive severe neuropathy in adulthood. This is associated with the prior failure to downregulate the biogenic program upon entering the homeostatic state leading to hypertrophy and hypermyelination of the mSCs, progressing to the development of severe myelination defects. Our results highlight distinct roles of HDAC1/2 and HDAC3 in controlling the differentiation and homeostatic states of a cell with broad implications for the understanding of this important cell-state transition.

Indexed as

HomeostasisAgingAnimalsHistone Deacetylase 3Histone DeacetylasesMice, Inbred C57BLMyelin SheathRatsSchwann CellsSciatic NerveTranscription, GeneticHistone Deacetylase 3Histone DeacetylasesbiogenesisHDACshomeostasisneuropathyperipheral nerveSchwann cells

Identifiers

PMID30517863
PMCPMC6293966
OpenAlexW2903152887

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.