ArticleThe Journal of infectious diseases2019
Minimally Invasive Saliva Testing to Monitor Norovirus Infection in Community Settings.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Rural targeted messaging, multiplex salivary measurement, and rural equity in SARS-CoV-2 antibody testing: Protocol overview of a SeroNet investigation.Contemporary clinical trials communications · 2026Article
- Development of an enteric pathogen multiplex immunoassay to measure antibody responses in blood and saliva for integrated serology applications.Journal of immunological methods · 2025Article
- Culturally targeted messaging and racial equity in SARS-CoV-2 antibody testing by multiplex salivary measurement: Protocol overview of a SeroNet investigation.Brain, behavior, & immunity - health · 2025Article
- Article
- Probing the Affinity of Coronavirus with Contact Surfaces in Simulated Body Fluids.Environment & health (Washington, D.C.) · 2024Article
- Exploring Natural Immune Responses toOpen forum infectious diseases · 2024Article
- Transcriptome analysis of salivary glands of rabies-virus-infected mice.Frontiers in microbiology · 2024Article
- Salivary diagnostics of the novel coronavirus SARS-CoV-2 (COVID-19).Oral diseases · 2022Review
- Salivary Antibodies against Multiple Environmental Pathogens Found in Individuals Recreating at an Iowa Beach.International journal of environmental research and public health · 2021Article
- Non-Invasive Antibody Assessment in Saliva to Determine SARS-CoV-2 Exposure in Young Children.Frontiers in immunology · 2021Observational
- COVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in Saliva.Journal of clinical microbiology · 2020Article
- Article
- Humoral and Mucosal Immune Responses to Human Norovirus in the Elderly.The Journal of infectious diseases · 2020Article
- Enteropathogen antibody dynamics and force of infection among children in low-resource settings.eLife · 2019Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundNorovirus is a leading cause of acute gastroenteritis worldwide. Routine norovirus diagnosis requires stool collection. The goal of this study was to develop and validate a noninvasive method to diagnose norovirus to complement stool diagnostics and to facilitate studies on transmission.
methodsA multiplex immunoassay to measure salivary immunoglobulin G (IgG) responses to 5 common norovirus genotypes (GI.1, GII.2, GII.4, GII.6, and GII.17) was developed. The assay was validated using acute and convalescent saliva samples collected from Peruvian children <5 years of age with polymerase chain reaction (PCR)-diagnosed norovirus infections (n = 175) and controls (n = 32). The assay sensitivity and specificity were calculated to determine infection status based on fold rise of salivary norovirus genotype-specific IgG using norovirus genotype from stool as reference.
resultsThe salivary assay detected recent norovirus infections and correctly assigned the infecting genotype. Sensitivity was 71% and specificity was 96% across the evaluated genotypes compared to PCR-diagnosed norovirus infection.
conclusionsThis saliva-based assay will be a useful tool to monitor norovirus transmission in high-risk settings such as daycare centers or hospitals. Cross-reactivity is limited between the tested genotypes, which represent the most commonly circulating genotypes.
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Registered trials
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