Evidence map›Paper›PMID 30517648›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2019

Left atrial function in heart failure with mid-range ejection fraction differs from that of heart failure with preserved ejection fraction: a 2D speckle-tracking echocardiographic study.

Lamia Al Saikhan, Alun D Hughes, Wing-See Chung, Maryam Alsharqi, Petros Nihoyannopoulos

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

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  5. Left Atrial Strain-Current Review of Clinical Applications.Diagnostics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Lamia Al SaikhanImperial College London (National Heart and Lung Institute), Hammersmith Hospital, Du Cane Road, London, UK.
Alun D HughesDepartment of Population Science & Experimental Medicine, Institute of Cardiovascular Science, University College London, Gower street, London, UK.
Wing-See ChungCardiology Department, Hammersmith Hospital, Du Cane Road, London, UK.
Maryam AlsharqiImperial College London (National Heart and Lung Institute), Hammersmith Hospital, Du Cane Road, London, UK.
Petros NihoyannopoulosImperial College London (National Heart and Lung Institute), Hammersmith Hospital, Du Cane Road, London, UK.
Hammersmith Hospital · GBUniversity College London · GB

Funding

British Heart Foundation CS/13/1/30327British Heart Foundation CS/15/6/31468British Heart Foundation PG/15/75/31748Medical Research Council MC_UU_12019/1
6 · The paper itself

Abstract

aimsHeart failure (HF) with mid-range ejection fraction (HFmrEF) shares similar diagnostic criteria to HF with preserved ejection fraction (HFpEF). Whether left atrial (LA) function differs between HFmrEF and HFpEF is unknown. We, therefore, used 2D-speckle-tracking echocardiography (2D-STE) to assess LA phasic function in patients with HFpEF and HFmrEF. METHODS AND

resultsConsecutive outpatients diagnosed with HF according to current European recommendations were prospectively enrolled. There were 110 HFpEF and 61 HFmrEF patients with sinus rhythm, and 37 controls matched by age. LA phasic function was analysed using 2D-STE. Peak-atrial longitudinal strain (PALS), peak-atrial contraction strain (PACS), and PALS-PACS were measured reflecting LA reservoir, pump, and conduit function, respectively. Among HF groups, most of left ventricular (LV) diastolic function measures, and LA volume were similar. Both HF groups had abnormal LA phasic function compared with controls. HFmrEF patients had worse LA phasic function than HFpEF patients even among patients with LA enlargement. Among patients with normal LA size, LA reservoir, and pump function remained worse in HFmrEF. Differences in LA phasic function between HF groups remained significant after adjustment for confounders. Global PALS and PACS were inversely correlated with brain natriuretic peptide, LA volume, E/A, E/e', pulmonary artery systolic pressure, and diastolic dysfunction grade in both HF groups.

conclusionLA phasic function was worse in HFmrEF patients compared with those with HFpEF regardless of LA size, and independent of potential confounders. These differences could be attributed to intrinsic LA myocardial dysfunction perhaps in relation to altered LV function.

Indexed as

Image Interpretation, Computer-AssistedAgedAnalysis of VarianceAtrial Function, LeftCase-Control StudiesCohort StudiesEchocardiographyFemaleHeart FailureHumansLinear ModelsMaleMiddle AgedMultivariate AnalysisSeverity of Illness IndexStatistics, Nonparametricatrial strainHFmrEFHFpEFspeckle-tracking echocardiography

Identifiers

PMID30517648
PMCPMC6383056
OpenAlexW2903434009

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.