Evidence map›Paper›PMID 30517338›Full record

ArticleJornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia

Does methylene blue attenuate inflammation in nonischemic lungs after lung transplantation?

Marcus da Matta Abreu, Francine Maria de Almeida, Kelli Borges Dos Santos, Emílio Augusto Campos Pereira de Assis, Rafael Kenji Fonseca Hamada, Fabio Biscegli Jatene, Paulo Manuel Pêgo-Fernandes, Rogerio Pazetti

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PubMed Full text at PMC Publisher
In one paragraph

Article in Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 75% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marcus da Matta Abreu. Departamento de Cardiopneumologia, Disciplina de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.ORCID http://orcid.org/0000-0002-4910-6266
Francine Maria de Almeida. Departamento de Cardiopneumologia, Disciplina de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.ORCID http://orcid.org/0000-0001-9755-5034
Kelli Borges Dos Santos. Núcleo de Pesquisa em Transplante, Faculdade de Enfermagem, Universidade Federal de Juiz de Fora, Juiz de Fora (MG) Brasil.ORCID http://orcid.org/0000-0001-8423-9147
Emílio Augusto Campos Pereira de Assis. Departamento de Patologia, Faculdade de Ciências Médicas e da Saúde de Juiz de Fora, Juiz de Fora (MG) Brasil.ORCID http://orcid.org/0000-0002-1326-9872
Rafael Kenji Fonseca Hamada. Faculdade de Medicina, Universidade Federal de Juiz de Fora, Juiz de Fora (MG) Brasil.ORCID http://orcid.org/0000-0002-7540-3141
Fabio Biscegli Jatene. Departamento de Cardiopneumologia, Disciplina de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.ORCID http://orcid.org/0000-0001-6175-5595
Paulo Manuel Pêgo-Fernandes. Departamento de Cardiopneumologia, Disciplina de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.ORCID http://orcid.org/0000-0001-7243-5343
Rogerio Pazetti. Departamento de Cardiopneumologia, Disciplina de Cirurgia Torácica, Instituto do Coração, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo (SP) Brasil.ORCID http://orcid.org/0000-0001-9823-7783
Universidade de São Paulo · BRUniversidade Federal de Juiz de Fora · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate whether methylene blue (MB) could minimize the effects of ischemia-reperfusion injury in the nonischemic lung on a lung transplantation rodent model.

methodsForty female Sprague-Dawley rats were divided into 20 donors and 20 recipients. The 20 recipient rats were divided into two groups (n = 10) according to the treatment (0.9% saline vs. 1% MB solutions). All animals underwent unilateral lung transplantation. Recipients received 2 mL of saline or MB intraperitoneally prior to transplantation. After 2 h of reperfusion, the animals were euthanized and histopathological and immunohistochemical analyses were performed in the nonischemic lung.

resultsThere was a significant decrease in inflammation-neutrophil count and intercellular adhesion molecule-1 (ICAM-1) expression in lung parenchyma were higher in the saline group in comparison with the MB group-and in apoptosis-caspase-3 expression was higher in the saline group and Bcl-2 expression was higher in MB group.

conclusionsMB is an effective drug for the protection of nonischemic lungs against inflammation and apoptosis following unilateral lung transplantation in rats.

Indexed as

AnimalsApoptosisFemaleImmunohistochemistryInflammationLung TransplantationMethylene BlueRatsRats, Sprague-DawleyReperfusion InjuryMethylene Blue

Identifiers

PMID30517338
PMCPMC6467587
OpenAlexW2903240885

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.