Evidence map›Paper›PMID 30516472›Full record

ArticleeLife2018

Spliceosome factors target timeless (

Iryna Shakhmantsir, Soumyashant Nayak, Gregory R Grant, Amita Sehgal

Open access · goldAbstract read
In one paragraph

Article in eLife, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
6.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
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  6. An intron-based timer for circadian rhythms.bioRxiv : the preprint server for biology · 2025
    Article
  7. Coevolution ofiScience · 2025
    Article
  8. Alternative splicing ofProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Integration of photoperiodic and temperature cues by the circadian clock to regulate insect seasonal adaptations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024
    Review
  10. Alternative splicing ofbioRxiv : the preprint server for biology · 2024
    Article
  11. Timeless noncoding DNA contains cell-type preferential enhancers important for proper Drosophila circadian regulation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Iryna ShakhmantsirChronobiology Program at Penn, Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-2138-0236
Soumyashant NayakThe Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Gregory R GrantThe Institute for Translational Medicine and Therapeutics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.
Amita SehgalChronobiology Program at Penn, Howard Hughes Medical Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, United States.ORCID 0000-0001-7354-9641
Howard Hughes Medical Institute · USTranslational Therapeutics (United States) · US

Funding

Cycling in a circadian circuitR37NS048471 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI SEHGAL, AMITA · 2015 to 2021
$2.7M
NCATS NIH HHS UL1TR001817NINDS NIH HHS R37 NS048471NINDS NIH HHS R37NS048471
6 · The paper itself

Abstract

Transcription-translation feedback loops that comprise eukaryotic circadian clocks rely upon temporal delays that separate the phase of active transcription of clock genes, such as Drosophila Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).

Indexed as

Feedback, PhysiologicalRNA SplicingAnimalsCircadian ClocksCircadian RhythmCLOCK ProteinsDrosophila melanogasterDrosophila ProteinsExonsIntronsNuclear ProteinsPeriod Circadian ProteinsProtein Serine-Threonine KinasesRibonucleoproteins, Small NuclearRNA, MessengerSequence Analysis, RNACG7028 protein, DrosophilaClk protein, DrosophilaCLOCK ProteinsDrosophila ProteinsNuclear ProteinsPeriod Circadian ProteinsPER protein, DrosophilaProtein Serine-Threonine KinasesRibonucleoproteins, Small NuclearRNA, Messengertim protein, Drosophilacircadian rhythmsD. melanogasterDrosophilafeedback loopgeneticsgenomicsmolecular clocksplicingtimeless

Identifiers

PMID30516472
PMCPMC6281371
OpenAlexW2903236847

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.