ArticleJournal of biomechanical engineering2019
Fundamental Roles of Axial Stretch in Isometric and Isobaric Evaluations of Vascular Contractility.
Article in Journal of biomechanical engineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Inverse finite element identification of murine aortic material properties:Computer methods in biomechanics and biomedical engineering · 2025Article
- Short-term disruption of TGF-β signaling in adult mice renders the aorta vulnerable to hypertension-induced dissection.JCI insight · 2025Article
- Instability in Computational Models of Vascular Smooth Muscle Cell Contraction.Annals of biomedical engineering · 2024Article
- β-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- β-aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice.bioRxiv : the preprint server for biology · 2024Article
- A computational bridge between traction force microscopy and tissue contraction.Journal of applied physics · 2023Article
- Smooth muscle contribution to vaginal viscoelastic response.Journal of the mechanical behavior of biomedical materials · 2023Article
- Role of smooth muscle activation in the static and dynamic mechanical characterization of human aortas.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Characterization of the active response of a guinea pig carotid artery.Frontiers in bioengineering and biotechnology · 2022Article
- Developmental origins of mechanical homeostasis in the aorta.Developmental dynamics : an official publication of the American Association of Anatomists · 2021Article
- An integrated set-up for ex vivo characterisation of biaxial murine artery biomechanics under pulsatile conditions.Scientific reports · 2021Article
- Mechanisms of Hypoxia-Induced Pulmonary Arterial Stiffening in Mice Revealed by a Functional Genetics Assay of Structural, Functional, and Transcriptomic Data.Frontiers in physiology · 2021Article
- [Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.Journal of hypertension · 2020Article
- Measuring Arterial Stiffness in Animal Experimental Studies.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Biomechanical characterization of murine pulmonary arteries.Journal of biomechanics · 2019Article
- Maladaptive aortic remodeling in hypertension associates with dysfunctional smooth muscle contractility.American journal of physiology. Heart and circulatory physiology · 2019Article
- The MAASWERP Study: An International, Comparative Case Study on Measuring Biomechanics of the Aged Murine Aorta.Pulse (Basel, Switzerland)Article
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3 authors at 1 institution in 1 country.
Funding
Abstract
Vascular smooth muscle cells (VSMCs) can regulate arterial mechanics via contractile activity in response to changing mechanical and chemical signals. Contractility is traditionally evaluated via uniaxial isometric testing of isolated rings despite the in vivo environment being very different. Most blood vessels maintain a locally preferred value of in vivo axial stretch while subjected to changes in distending pressure, but both of these phenomena are obscured in uniaxial isometric testing. Few studies have rigorously analyzed the role of in vivo loading conditions in smooth muscle function. Thus, we evaluated effects of uniaxial versus biaxial deformations on smooth muscle contractility by stimulating two regions of the mouse aorta with different vasoconstrictors using one of three testing protocols: (i) uniaxial isometric testing, (ii) biaxial isometric testing, and (iii) axially isometric plus isobaric testing. Comparison of methods (i) and (ii) revealed increased sensitivity and contractile capacity to potassium chloride and phenylephrine (PE) with biaxial isometric testing, and comparison of methods (ii) and (iii) revealed a further increase in contractile capacity with isometric plus isobaric testing. Importantly, regional differences in estimated in vivo axial stretch suggest locally distinct optimal biaxial configurations for achieving maximal smooth muscle contraction, which can only be revealed with biaxial testing. Such differences highlight the importance of considering in vivo loading and geometric configurations when evaluating smooth muscle function. Given the physiologic relevance of axial extension and luminal pressurization, we submit that, when possible, axially isometric plus isobaric testing should be employed to evaluate vascular smooth muscle contractile function.
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