ArticleClinical pharmacology and therapeutics2019
Pharmacogene Variation Consortium Gene Introduction: NUDT15.
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Article in Clinical pharmacology and therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
–field-weighted citation impact
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Personalized Therapy with Mercaptopurine in Acute Lymphoblastic Leukemia: Current Advances and Challenges.Current treatment options in oncology · 2026Review
- Severe Thiopurine-Induced Myelosuppression in a Pediatric Acute Lymphoblastic Leukemia Patient With the NUDT15 *1/*6 Genotype: A Brief Report.Clinical and translational science · 2026Article
- Predictive role of ITPA genetic variants in thiopurine-related myelotoxicity in Crohn's disease patients.The pharmacogenomics journal · 2024Article
- A comprehensive Thai pharmacogenomics database (TPGxD-1): Phenotype prediction and variants identification in 942 whole-genome sequencing data.Clinical and translational science · 2024Article
- Pharmacogenetics of 6-mercaptopurine in a black Zimbabwean cohort treated for acute lymphoblastic leukaemia.Pharmacogenomics · 2023Article
- Article
- Nudix hydrolase 15 (NUDT15) loss-of-function variants in an Australian inflammatory bowel disease population.Internal medicine journal · 2022Article
- Long-read HiFi sequencing of NUDT15: Phased full-gene haplotyping and pharmacogenomic allele discovery.Human mutation · 2022Article
- TPMT and NUDT15 Genotyping Recommendations: A Joint Consensus Recommendation of the Association for Molecular Pathology, Clinical Pharmacogenetics Implementation Consortium, College of American Pathologists, Dutch Pharmacogenetics Working Group of the Royal Dutch Pharmacists Association, European Society for Pharmacogenomics and Personalized Therapy, and Pharmacogenomics Knowledgebase.The Journal of molecular diagnostics : JMD · 2022Review
- Characterization of Reference Materials for TPMT and NUDT15: A GeT-RM Collaborative Project.The Journal of molecular diagnostics : JMD · 2022Article
- A direct sequencing assay for pharmacogenetic testing of thiopurine-intolerant NUDT15 alleles in an Asian population.BMC research notes · 2022Article
- Review
- Pharmacogene Variation Consortium: A Global Resource and Repository for Pharmacogene Variation.Clinical pharmacology and therapeutics · 2021Article
- Population impact of pharmacogenetic tests in admixed populations across the Americas.The pharmacogenomics journal · 2021Article
- Quantification of Thioguanine in DNA Using Liquid Chromatography-Tandem Mass Spectrometry for Routine Thiopurine Drug Monitoring in Patients With Pediatric Acute Lymphoblastic Leukemia.Annals of laboratory medicine · 2021Article
- Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants.Pediatric research · 2021Article
- Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study.Frontiers in pharmacology · 2021Article
- Meta-Analysis ofFrontiers in pharmacology · 2021Review
- Association ofGenes · 2020Article
- Massively parallel variant characterization identifiesProceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Jun J YangDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Michelle Whirl-CarrilloDepartment of Biomedical Data Science, Stanford University, Stanford, California, USA.
Stuart A ScottDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-5720-1864
Amy J TurnerDepartment of Pediatrics, Section of Genomic Pediatrics and Children's Research Institute, The Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Matthias SchwabDr Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.ORCID 0000-0002-9984-075X
Yoichi TanakaDepartment of Clinical Pharmacy, School of Pharmacy, Kitasato University, Shirokane, Minato-ku, Tokyo, Japan.
Guilherme Suarez-KurtzCoordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, Brazil.
Elke SchaeffelerRPRD Diagnostics LLC, Wauwatosa, Wisconsin, USA.
Teri E KleinDepartment of Biomedical Data Science, Stanford University, Stanford, California, USA.
Neil A MillerCenter for Pediatric Genomic Medicine, Children's Mercy Kansas City, Kansas City, Missouri, USA.ORCID 0000-0002-6151-4780
Andrea GaedigkSchool of Medicine, University of Missouri-Kansas City, Kansas City, Missouri, USA.ORCID 0000-0001-6968-1893
Funding
PharmGKB: pharmacogenomics knowledge for precision medicineR24GM061374 · NIGMS · STANFORD UNIVERSITY · PI ALTMAN, RUSS BIAGIO, KLEIN, TERI ELLEN · 2010 to 2018
$25.2MCPML - Project 3: Genome-wide Studies of Adverse EffectsP50GM115279 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI LOH, MIGNON LEE-CHEUN, RELLING, MARY V · 2015 to 2019
$15.1MGenetics-guided Individualization of Thiopurine TherapyR01GM118578 · NIGMS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI YANG, JUN J. · 2017 to 2020
$2.2MPHARMacogene VARiation ConsortiumR24GM123930 · NIGMS · CHILDREN'S MERCY HOSP (KANSAS CITY, MO) · PI GAEDIGK, ANDREA · 2017 to 2020
$1.9MNIGMS NIH HHS P50 GM115279NIGMS NIH HHS R01 GM118578NIGMS NIH HHS R24 GM061374NIGMS NIH HHS R24 GM123930
Abstract
PubMed holds no abstract for this paper.
Indexed as
BiotransformationPharmacogenomic VariantsAllelesCytochrome P-450 Enzyme SystemGenome-Wide Association StudyHaplotypesHumansMedication Therapy ManagementNudix HydrolasesPharmacogeneticsPharmacogenomic TestingPyrophosphatasesTerminology as TopicCytochrome P-450 Enzyme SystemNudix HydrolasesNUDT15 protein, humanPyrophosphatases
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.