ArticleMolecular biology reports2019
Synergistic effects of TIMP2-418G/C and MMP9-1562C/T variants on the male infertility risk.
Article in Molecular biology reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Association between the FAS/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2019Pooled it
- Assessment of the relationship between miR-499C/T (rs3746444) polymorphism and lung carcinoma in Iranian population; a case-control study.African health sciences · 2023Article
- Genetics and molecular biology of male infertility among Iranian population: an update.American journal of translational research · 2021Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) involve in the degradation of the extracellular matrix (ECM) that imbalances their activity and may lead to various diseases. The present study aims to evaluate the association between MMP9-1562C/T and TIMP2-418G/C variants and synergistic effects of both variants on male infertility in an Iranian population. We analyzed these polymorphisms in 101 infertile men and 106 fertile men as a control group using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique. Based on the obtained results, no considerable association was observed in MMP9-1562C/T polymorphism frequency between infertile men and controls while frequencies of TIMP2-418G/C variant were significantly different in infertile and control groups (P = 0.028). Men with CC, GC and CC + GC genotypes for TIMP2-418G/C polymorphism had an increased risk of infertility compared to men with GG genotype [OR = 1.85, 95% CI (0.917-3.734, P = 0.086), OR = 1.94, 95% CI (1.098-3.437, P = 0.023) and OR = 2.053 95% CI (1.179-3.577, P = 0.011), respectively]. Also, in the presence of both TIMP2-418C and MMP9-1562T alleles the male infertility risk was significantly increased (P = 0.032). The current study suggests that the variation of TIMP2 gene and its interaction with MMP9 gene might be associated with male infertility. However, to confirm these findings, further studies are required in different ethnicities and with a larger sample size.
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Registered trials
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