Evidence map›Paper›PMID 30515432›Full record

ArticleOpen forum infectious diseases2018

Serum Albumin Is Associated With Higher Inflammation and Carotid Atherosclerosis in Treated Human Immunodeficiency Virus Infection.

Sahera Dirajlal-Fargo, Manjusha Kulkarni, Emily Bowman, Lingpeng Shan, Abdus Sattar, Nicholas Funderburg, Grace A McComsey

Open access · goldAbstract read
In one paragraph

Article in Open forum infectious diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

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  10. Systemic inflammation response index predicts the postoperative recurrence of chronic rhinosinusitis with nasal polyps: a retrospective study in the Chinese population.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024
    Article
  11. Article
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  13. Proteomic Studies of Blood and Vascular Wall in Atherosclerosis.International journal of molecular sciences · 2021
    Review
  14. Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy.Colloids and surfaces. B, Biointerfaces · 2021
    Article
  15. Article
  16. A simple and readily available inflammation-based risk scoring system on admission predicts the need for mechanical ventilation in patients with COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Sahera Dirajlal-FargoUniversity Hospitals Cleveland Medical Center, Ohio.
Manjusha KulkarniOhio State University School of Health and Rehabilitation Sciences, Columbus.
Emily BowmanOhio State University School of Health and Rehabilitation Sciences, Columbus.
Lingpeng ShanCase Western Reserve University, Cleveland, Ohio.
Abdus SattarCase Western Reserve University, Cleveland, Ohio.
Nicholas FunderburgOhio State University School of Health and Rehabilitation Sciences, Columbus.
Grace A McComseyUniversity Hospitals Cleveland Medical Center, Ohio.
The Ohio State University · USCase Western Reserve University · USRainbow Babies & Children's Hospital · USUniversity Hospitals of Cleveland · US

Funding

Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
Inflammation, Heart and BoneR01NR012642 · NINR · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2010 to 2014
$2.5M
Cardiovascular disease and inflammation in Ugandan children with HIVK23HD088295 · NICHD · CASE WESTERN RESERVE UNIVERSITY · PI DIRAJLAL-FARGO, SAHERA · 2016 to 2020
$799k
Tissue factor expression in HIV disease - Implications for cardiovascular riskR00HL108743 · NHLBI · OHIO STATE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2014 to 2016
$747k
Tissue factor expression in HIV disease - Implications for cardiovascular riskK99HL108743 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI FUNDERBURG, NICHOLAS T. · 2012 to 2013
$178k
NCATS NIH HHS UM1 TR004528NHLBI NIH HHS K99 HL108743NHLBI NIH HHS R00 HL108743NICHD NIH HHS K23 HD088295NINR NIH HHS R01 NR012642
6 · The paper itself

Abstract

backgroundThis study was conducted to explore the associations between serum albumin and markers of inflammation and cardiovascular disease in treated human immunodeficiency virus (HIV)-infected adults.

methodsWe conducted a nested study within in the SATURN-HIV trial in which 147 HIV

resultsMean age was 45 years, 80% of participants were male, and 69% were African American. Mean serum albumin was similar between the groups at all time points (4.01-4.09 g/dL in statin arm vs 4.02-4.11 g/dL in placebo arm;

conclusionsLower serum albumin in controlled HIV is associated with higher markers of chronic inflammation and hypercoagulation, which could explain the prior observation that serum albumin predicts nonacquired immune deficiency syndrome events in HIV. Serum albumin may predict progression of carotid atherosclerosis independent of traditional risk factors.

Indexed as

albumincardiovascular diseasegut integrityHIVimmune activation

Identifiers

PMID30515432
PMCPMC6262118
OpenAlexW2900699668

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.