Evidence map›Paper›PMID 30515314›Full record

ArticleJournal of virus eradication2018

Mathematical modelling to inform 'treat all' implementation in sub-Saharan Africa: a scoping review.

April D Kimmel, Rose S Bono, Olivia Keiser, Jean D Sinayobye, Janne Estill, Deo Mujwara, Olga Tymejczyk, Denis Nash

Open access · goldAbstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

April D KimmelDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond VA, USA.
Rose S BonoDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond VA, USA.
Olivia KeiserInstitute of Global Health, University of Geneva, Switzerland.
Jean D SinayobyeResearch and Clinical Education Division, Rwanda Military Hospital, Kigali, Rwanda.
Janne Estill
Deo MujwaraDepartment of Health Behavior and Policy, Virginia Commonwealth University, Richmond VA, USA.
Olga Tymejczyk
Denis Nash
Virginia Commonwealth University · USCity University of New York · USUniversity of Geneva · CHRwanda Military Hospital · RW

Funding

"Enhancing Cancer Research in Central Africa IeDEA"U01AI096299 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Denis Nash, Marcel Yotebieng · 2011 to 2026
$35.8M
All Africa IeDEA ConferenceR13AI134393 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ANASTOS, KATHRYN M., NASH, DENIS · 2017 to 2017
$85k
NIAID NIH HHS R13 AI134393NIAID NIH HHS U01 AI096299
6 · The paper itself

Abstract

objectiveDespite widespread uptake, only half of sub-Saharan African countries have fully implemented the World Health Organization's 'treat all' policy, hindering achievement of global HIV targets. We examined literature on mathematical modelling studies that sought to inform scale-up and implementation of 'treat all' in sub-Saharan Africa.

methodsWe conducted a scoping review, a research synthesis to assess emerging evidence and identify gaps, of peer-reviewed literature, extracting study characteristics on 'treat all' policies and assumptions, setting, key populations, outcomes and findings. Studies were narratively summarised and potential gaps characterised.

resultsWe identified 16 studies examining 'treat all' alone (

conclusionsThe modelling literature demonstrates improved health and economic benefits of 'treat all'. Using mathematical modelling to inform real-world implementation of 'treat all' requires realistic assumptions about expanded testing and care continuum interventions across a wide range of settings and populations.

Indexed as

HIV, mathematical modelling, treat all, sub-Saharan Africa

Identifiers

PMID30515314
PMCPMC6248854
OpenAlexW3021106884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.