Evidence map›Paper›PMID 30515312›Full record

ArticleJournal of virus eradication2018

Achieving UNAIDS 90-90-90 targets for pregnant and postpartum women in sub-Saharan Africa: progress, gaps and research needs.

Lisa L Abuogi, John M Humphrey, Christian Mpody, Marcel Yotebieng, Pamela M Murnane, Kate Clouse, Lindah Otieno, Craig R Cohen, Kara Wools-Kaloustian

Abstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. International journal of MCH and AIDS · 2025
    Article
  14. Predictors of Human Immunodeficiency Virus (HIV) Acquisition among children 0-14 Years in Nigeria.International journal of translational medical research and public health · 2025
    Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lisa L AbuogiDepartment of Pediatrics, University of Colorado, Denver, Aurora, CO, USA.
John M HumphreyDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Christian MpodyDivision of Epidemiology, Ohio State University, Columbus, OH, USA.
Marcel YotebiengDivision of Epidemiology, Ohio State University, Columbus, OH, USA.
Pamela M MurnaneCenter for AIDS Prevention Studies, University of California San Francisco, San Francisco, CA, USA.
Kate ClouseVanderbilt Institute for Global Health, Vanderbilt University, Nashville, TN, USA.
Lindah OtienoCenter for Microbial Research, Research Care and Training Program, Kenya Medical Research Institute, Nairobi, Kenya.
Craig R CohenDepartment of Obstetrics, Gynecology & Reproductive Sciences, University of California San Francisco, CA, USA.
Kara Wools-KaloustianDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

East Africa International Epidemiology Database to evaluate AIDS (IeDEA) Regional ConsortiumU01AI069911 · NIAID · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Leslie Anne Enane, AGGREY SEMWENDERO SEMEERE · 2006 to 2026
$57.7M
Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
TRAINEESHIPS IN AIDS PREVENTION STUDIEST32MH019105 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Carol Suzanne Camlin, Glenn-Milo Santos · 1989 to 2026
$15.3M
Long term outcomes of therapy in women initiated on lifelong ART because of pregnancy in DR CongoR01HD087993 · NICHD · OHIO STATE UNIVERSITY · PI BABAKAZO, PELAGIE DIAMBALULA, YOTEBIENG, MARCEL · 2016 to 2020
$3.1M
NIAID NIH HHS U01 AI069911NICHD NIH HHS R01 HD087993NIMH NIH HHS P30 MH062246NIMH NIH HHS T32 MH019105
6 · The paper itself

Abstract

The implementation of the 2013 World Health Organization Option B+ recommendations for HIV treatment during pregnancy has helped drive significant progress in achieving universal treatment for pregnant and postpartum women in sub-Saharan Africa (SSA). Yet, critical research and implementation gaps exist in achieving the UNAIDS 90-90-90 targets. To help guide researchers, programmers and policymakers in prioritising these areas, we undertook a comprehensive review of the progress, gaps and research needs to achieve the 90-90-90 targets for this population in the Option B+ era, including early infant HIV diagnosis (EID) for HIV-exposed infants. Salient areas where progress has been achieved or where gaps remain include: (1) knowledge of HIV status is higher among people with HIV in southern and eastern Africa compared to western and central Africa (81% versus 48%, UNAIDS); (2) access to antiretroviral therapy (ART) for pregnant women has doubled in 22 of 42 SSA countries, but only six have achieved the second 90, and nearly a quarter of pregnant women initiating ART become lost to follow-up; (3) viral suppression data for this population are sparse (estimates range from 30% to 98% peripartum), with only half of women maintaining suppression through 12 months postpartum; and (4) EID rates range from 15% to 62%, with only three of 21 high-burden SSA countries testing >50% HIV-exposed infants within the first 2 months of life. We have identified and outlined promising innovations and research designed to address these gaps and improve the health of pregnant and postpartum women living with HIV and their infants.

Indexed as

prevention of mother-to-child transmission, prevention of vertical transmission, HIV, pregnancy, postpartum, sub-Saharan Africa

Identifiers

PMID30515312
PMCPMC6248851

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.