ArticleOncotarget2018
Histologic subtyping in pathologic stage I-IIA lung adenocarcinoma provides risk-based stratification for surveillance.
Article in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Prognostic Impact of Inadequate Lymph Node Evaluation in Early-Stage Lung Adenocarcinoma with Micropapillary or Solid Components.Annals of surgical oncology · 2026Article
- Evaluation of high-grade growth patterns in invasive adenocarcinomas manifesting as ground-glass lesions via clinical and qualitative and quantitative computed tomography features.Quantitative imaging in medicine and surgery · 2026Article
- Prediction of high-grade patterns of stage IA lung invasive adenocarcinoma based on high-resolution CT features: a bicentric study.European radiology · 2023Article
- Micropapillary and Solid Histologic Patterns in N1 and N2 Lymph Node Metastases Are Independent Factors of Poor Prognosis in Patients With Stages II to III Lung Adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2023Article
- Establishment and validation of a radiological-radiomics model for predicting high-grade patterns of lung adenocarcinoma less than or equal to 3 cm.Frontiers in oncology · 2022Article
- Comprehensive analysis of the clinicopathological features, targetable profile, and prognosis of mucinous adenocarcinoma of the lung.Journal of cancer research and clinical oncology · 2021Article
- Radiomics-guided deep neural networks stratify lung adenocarcinoma prognosis from CT scans.Communications biology · 2021Article
- Deep Learning Analysis of CT Images Reveals High-Grade Pathological Features to Predict Survival in Lung Adenocarcinoma.Cancers · 2021Article
- Rethinking a Non-Predominant Pattern in Invasive Lung Adenocarcinoma: Prognostic Dissection Focusing on a High-Grade Pattern.Cancers · 2021Article
- Sarcopenia is poor risk for unfavorable short- and long-term outcomes in stage I non-small cell lung cancer.Annals of translational medicine · 2021Article
- Prognostic impact of micropapillary component in patients with node-negative subcentimeter lung adenocarcinoma: A Chinese cohort study.Thoracic cancer · 2020Article
- The Underlying Tumor Genomics of Predominant Histologic Subtypes in Lung Adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2020Article
- CT-Guided Core Biopsy for Peripheral Sub-solid Pulmonary Nodules to Predict Predominant Histological and Aggressive Subtypes of Lung Adenocarcinoma.Annals of surgical oncology · 2020Article
- Thymidylate synthase (TS) immunostaining in the diagnosis of the myoepithelial cells, basal cells, stratified epithelium cells, and associated tumors.Translational cancer research · 2020Article
- Expansion of the Concept of Micropapillary Adenocarcinoma to Include a Newly Recognized Filigree Pattern as Well as the Classical Pattern Based on 1468 Stage I Lung Adenocarcinomas.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2019Article
- Challenges for real-time intraoperative diagnosis of high risk histology in lung adenocarcinoma: A necessity for sublobar resection.Thoracic cancer · 2019Review
- New Frontiers for Molecular Pathology.Frontiers in medicine · 2019Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundWe hypothesize that recurrence hazard following resection for stage I-IIA lung adenocarcinoma (ADC) varies according to histologic subtype, which may provide risk stratification for surveillance better than the current uniform follow-up protocol.
resultsPresence (≥5%) of high-grade histologic subtypes (MIP and/or SOL) was associated with a significantly higher recurrence hazard: (1) presence of either MIP or SOL was associated with a significant increase in recurrence hazard during the first two years after surgery; (2) presence of SOL was associated with an increase in recurrence hazard-in particular, distant recurrence hazard-during the first year after surgery; (3) absence of high-grade subtypes (515/1,572 patients) was associated with a very low recurrence hazard (<2% risk/year) during the first ten years after surgery.
methodsAll hematoxylin and eosin-stained tumor slides from pathologic stage I-IIA lung ADC (
conclusionsOur findings suggest that histologic subtyping has utility for identifying recurrence hazard for surgically resected stage I-IIA lung ADC patients and provide rationale for establishing risk-based surveillance.
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