ArticleFrontiers in aging neuroscience2018
Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship.
Article in Frontiers in aging neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Education, Cognitive Reserve, and Brain Pathology in Aging and Alzheimer's Disease: Evidence from Preclinical and Symptomatic Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Advancements in dementia research, diagnostics, and care in Latin America: Highlights from the 2023 Alzheimer's Association International conference satellite symposium in Mexico City.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Resilience of Neural Cellularity to the Influence of Low Educational Level.Brain sciences · 2023Article
- No moderating influence of education on the association between changes in hippocampus volume and memory performance in aging.Aging brain · 2023Article
- Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Verbal intelligence is a more robust cross-sectional measure of cognitive reserve than level of education in healthy older adults.Alzheimer's research & therapy · 2021Article
- Distributed functional connectivity predicts neuropsychological test performance among older adults.Human brain mapping · 2021Article
- Neuroimaging Research on Dementia in Brazil in the Last Decade: Scientometric Analysis, Challenges, and Peculiarities.Frontiers in neurology · 2021Review
- Enhancing Cognitive Performance of Healthy Czech Seniors through Non-Native Language Learning-A Mixed-Methods Pilot Study.Brain sciences · 2020Article
- Moderating effect of cognitive reserve on the association between grey matter atrophy and memory varies with age in older adults.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2020Article
- Psychiatric neuroimaging research in Brazil: historical overview, current challenges, and future opportunities.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2020Article
- Environmental and Cognitive Enrichment in Childhood as Protective Factors in the Adult and Aging Brain.Frontiers in psychology · 2020Article
- The Figure Memory Test: diagnosis of memory impairment in populations with heterogeneous educational background.Dementia & neuropsychologiaArticle
- Health literacy, but not memory, is associated with hippocampal connectivity in adults with low levels of formal education.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
According to the cognitive reserve theory, intellectual stimuli acquired during life can prevent against developing cognitive impairment. The underlying cognitive reserve mechanisms were underexplored in low-educated individuals. Because episodic memory impairment due to hippocampal dysfunction is a key feature of Alzheimer's dementia (AD), we sought to look at a possible cognitive reserve mechanism by determining whether few years of education moderated the relationship between the hippocampal volumes and the episodic-memory scores. The sample was composed by 183 older adults, 40.1% male, with the median age of 78[76,82] years and the median years of education of 4[2,10] who had undergone an episodic-memory test and a 3-Tesla MRI scan to access the hippocampal volumes. Overall, 112 were cognitively healthy, 26 had cognitive impairment-no dementia (CIND) and 45 had dementia. We used multiple linear regression to assess whether the interaction between years of education and each hippocampal volume significantly predicted the episodic-memory scores' variance, controlling for cognitive diagnosis and nuisance variables. The interaction term with the left hippocampus (ß = 0.2,
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