ArticleScientific reports2018
Shared genetic aetiology between cognitive performance and brain activations in language and math tasks.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Pooled it
- Article
- Imaging genetics of language network functional connectivity reveals links with language-related abilities, dyslexia and handedness.Communications biology · 2024Article
- Processing Language Partly Shares Neural Genetic Basis with Processing Tools and Body Parts.eNeuro · 2024Article
- Are numerical abilities determined at early age? A brain morphology study in children and adolescents with and without developmental dyscalculia.Developmental cognitive neuroscience · 2024Article
- Genetic and environmental influence on resting state networks in young male and female adults: a cartographer mapping study.Human brain mapping · 2023Article
- Language network lateralization is reflected throughout the macroscale functional organization of cortex.Nature communications · 2023Article
- Determinants of Cognitive Performance in Children and Adolescents: A Populational Longitudinal Study.International journal of environmental research and public health · 2022Article
- Imaging Genetic Based Mediation Analysis for Human Cognition.Frontiers in neuroscience · 2022Article
- Gene Expression Correlates of the Cortical Network Underlying Sentence Processing.Neurobiology of language (Cambridge, Mass.) · 2020Article
- Estimating the heritability of psychological measures in the Human Connectome Project dataset.PloS one · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
Cognitive performance is highly heritable. However, little is known about common genetic influences on cognitive ability and brain activation when engaged in a cognitive task. The Human Connectome Project (HCP) offers a unique opportunity to study this shared genetic etiology with an extended pedigree of 785 individuals. To investigate this common genetic origin, we took advantage of the HCP dataset, which includes both language and mathematics activation tasks. Using the HCP multimodal parcellation, we identified areals in which inter-individual functional MRI (fMRI) activation variance was significantly explained by genetics. Then, we performed bivariate genetic analyses between the neural activations and behavioral scores, corresponding to the fMRI task accuracies, fluid intelligence, working memory and language performance. We observed that several parts of the language network along the superior temporal sulcus, as well as the angular gyrus belonging to the math processing network, are significantly genetically correlated with these indicators of cognitive performance. This shared genetic etiology provides insights into the brain areas where the human-specific genetic repertoire is expressed. Studying the association of polygenic risk scores, using variants associated with human cognitive ability and brain activation, would provide an opportunity to better understand where these variants are influential.
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