ArticleScientific reports2018
Evidence for divergent patterns of local selection driving venom variation in Mojave Rattlesnakes (Crotalus scutulatus).
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 67 citations in OpenAlex.
- Truncated Life History Underlies Rapid Local Adaptation in Island Rattlesnake Venom Expression.Genome biology and evolution · 2026Article
- Venom Variation as a Window into the Ecology and Evolution of Snakes.Integrative and comparative biology · 2026Review
- Phenotypic dichotomy in Crotalus durissus ruruima venom and potential consequences for clinical management of snakebite envenomations.PLoS neglected tropical diseases · 2025Article
- Snake Venomics of the Arboreal Talamancan Palm-Pitviper,Journal of proteome research · 2025Article
- Ambient temperature and toxic diets constrain snake venom resistance in a desert rodent.Biology letters · 2025Article
- Dietary Breadth Predicts Toxin Expression Complexity in the Venoms of North American Gartersnakes.Integrative organismal biology (Oxford, England) · 2025Article
- Where the "ruber" Meets the Road: Using the Genome of the Red Diamond Rattlesnake to Unravel the Evolutionary Processes Driving Venom Evolution.Genome biology and evolution · 2024Article
- The venom and telopodal defence systems of the centipede Lithobius forficatus are functionally convergent serial homologues.BMC biology · 2024Article
- Venom diversity in Naja mossambica: Insights from proteomic and immunochemical analyses reveal intraspecific differences.PLoS neglected tropical diseases · 2024Article
- Article
- Snakebite Envenoming in Avian Species: A Systematic Scoping Review and Practitioner Experience Survey.Journal of avian medicine and surgery · 2023Article
- Sequence Divergence in Venom Genes Within and Between Montane Pitviper (Viperidae: Crotalinae: Cerrophidion) Species is Driven by Mutation-Drift Equilibrium.Journal of molecular evolution · 2023Article
- Venom phenotype conservation suggests integrated specialization in a lizard-eating snake.Toxicon : official journal of the International Society on Toxinology · 2023Article
- Snakes on a plain: biotic and abiotic factors determine venom compositional variation in a wide-ranging generalist rattlesnake.BMC biology · 2023Article
- One Size Fits All-Venomics of the Iberian Adder (Toxins · 2023Article
- Montane Rattlesnakes in México: Venoms ofToxins · 2023Article
- The roles of balancing selection and recombination in the evolution of rattlesnake venom.Nature ecology & evolution · 2022Article
- Divergent Specialization of Simple Venom Gene Profiles among Rear-Fanged Snake Genera (Toxins · 2022Article
- VenomMaps: Updated species distribution maps and models for New World pitvipers (Viperidae: Crotalinae).Scientific data · 2022Article
- Varying Intensities of Introgression Obscure Incipient Venom-Associated Speciation in the Timber Rattlesnake (Toxins · 2021Article
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Authors and funding
17 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Snake venoms represent an enriched system for investigating the evolutionary processes that lead to complex and dynamic trophic adaptations. It has long been hypothesized that natural selection may drive geographic variation in venom composition, yet previous studies have lacked the population genetic context to examine these patterns. We leverage range-wide sampling of Mojave Rattlesnakes (Crotalus scutulatus) and use a combination of venom, morphological, phylogenetic, population genetic, and environmental data to characterize the striking dichotomy of neurotoxic (Type A) and hemorrhagic (Type B) venoms throughout the range of this species. We find that three of the four previously identified major lineages within C. scutulatus possess a combination of Type A, Type B, and a 'mixed' Type A + B venom phenotypes, and that fixation of the two main venom phenotypes occurs on a more fine geographic scale than previously appreciated. We also find that Type A + B individuals occur in regions of inferred introgression, and that this mixed phenotype is comparatively rare. Our results support strong directional local selection leading to fixation of alternative venom phenotypes on a fine geographic scale, and are inconsistent with balancing selection to maintain both phenotypes within a single population. Our comparisons to biotic and abiotic factors further indicate that venom phenotype correlates with fang morphology and climatic variables. We hypothesize that links to fang morphology may be indicative of co-evolution of venom and other trophic adaptations, and that climatic variables may be linked to prey distributions and/or physiology, which in turn impose selection pressures on snake venoms.
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