ArticleScientific reports2018
Dorsolateral and medial prefrontal cortex mediate the influence of incidental priming on economic decision making in obesity.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Abnormal changes of brain function and structure in patients with T2DM-related cognitive impairment: a neuroimaging meta-analysis and an independent validation.Nutrition & diabetes · 2024Pooled it
- Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.Diabetes, obesity & metabolism · 2025Article
- Article
- Multi-omics insights into the microbiota-gut-brain axis and cognitive improvement post-bariatric surgery.Journal of translational medicine · 2024Article
- Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions.Molecular psychiatry · 2023Review
- Reward and inhibition in obesity and cigarette smoking: Neurobiological overlaps and clinical implications.Physiology & behavior · 2023Review
- Brain alterations associated with overweight evaluated by body mass index or body fat index in an elderly population: the PROOF study.Frontiers in endocrinology · 2023Article
- Food cue reactivity: Neurobiological and behavioral underpinnings.Reviews in endocrine & metabolic disorders · 2022Review
- Whole-brain functional connectivity correlates of obesity phenotypes.Human brain mapping · 2020Article
- Is obesity related to enhanced neural reactivity to visual food cues? A review and meta-analysis.Social cognitive and affective neuroscience · 2020Article
- Altered Interactions Among Resting-State Networks in Individuals with Obesity.Obesity (Silver Spring, Md.) · 2020Article
- Article
- A meta-analysis of neural systems underlying delay discounting: Implications for transdiagnostic research.Imaging neuroscience (Cambridge, Mass.)Article
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3 authors.
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Abstract
Obese individuals discount future rewards to a higher degree than lean individuals, which is generally considered disadvantageous. Moreover, their decisions are altered more easily by decision-irrelevant cues. Here, we investigated neural correlates of this phenomenon using functional MRI. We tested 30 lean and 26 obese human subjects on a primed delay discounting paradigm using gustatory and visual cues of positive, neutral and negative valence to bias their intertemporal preferences. We hypothesised that activation differences in reward-related and behavioural control areas, and changes in connectivity between these areas, would reflect the effect of these cues. Here, obese subjects were more susceptible to priming with negative gustatory cues towards delayed choices as opposed to lean subjects. This was related to lower activity in the left dorsolateral prefrontal cortex during priming. Modulation of functional connectivity between the dlPFC and the ventromedial PFC by the behavioural priming effect correlated negatively with BMI. This might indicate that default goals of obese individuals were different from those of lean participants, as the dlPFC has been suggested to be involved in internal goal pursuit. The present results further our understanding of the role of the PFC in decision-making and might inform future weight-management approaches based on non-invasive brain stimulation.
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