ArticleThorax2019
Maternal history of miscarriages and measures of fertility in relation to childhood asthma.
Article in Thorax, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Association between childhood asthma and history of assisted reproduction techniques: a systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- The Long-Term Outcome of Children Conceived Through Assisted Reproductive Technology.Reproductive sciences (Thousand Oaks, Calif.) · 2024Review
- The risk of asthma in singletons conceived by ART: a retrospective cohort study.Human reproduction open · 2024Article
- Review
- Health of singletons born after frozen embryo transfer until early adulthood: a Finnish register study.Human reproduction (Oxford, England) · 2022Article
- Early childhood respiratory tract infections according to parental subfertility and conception by assisted reproductive technologies.Human reproduction (Oxford, England) · 2022Article
- Infertility treatment associated with childhood asthma and atopy.Human reproduction (Oxford, England) · 2022Article
- Malaria Infection Is Common and Associated With Perinatal Mortality and Preterm Delivery Despite Widespread Use of Chemoprevention in Mali: An Observational Study 2010 to 2014.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Observational
- Asthma in 9-year-old children of subfertile couples is not associated with in vitro fertilization procedures.European journal of pediatrics · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
backgroundIt remains unclear what underlies the greater risk of asthma reported among children conceived by assisted reproductive technologies (ART).
objectiveOur aim was to clarify the role of parental subfertility and unmeasured confounding on the association between ART and childhood asthma, and to examine the possibility for common mechanisms underlying parental subfertility and miscarriages influencing asthma pathogenesis.
methodsWe used data from national Norwegian health registries (n=474 402) and the Norwegian Mother and Child Cohort Study (MoBa) (n=75 797). We used log-linear regression to estimate overall associations, and fixed-effects logistic regression to estimate associations within siblings.
resultsART offspring had greater asthma risk, the adjusted relative risk (aRR) was 1.20 (95% CI 1.09 to 1.32) in the registry-based cohort, and 1.42 (95% CI 1.14 to 1.76) in MoBa. The sibling analysis yielded similar associations, although the CI included the null value. The elevated asthma risk among ART offspring was attenuated when they were compared with spontaneously conceived offspring with time to conception >12 months, aRR 1.22 (95% CI 0.95 to 1.57). Asthma risk also increased with maternal history of early miscarriages (≤12 weeks), with an aRR of 1.07 (95% CI 1.03 to 1.11) for one, aRR 1.18 (95% CI 1.10 to 1.26) for two and aRR 1.24 (95% CI 1.12 to 1.37) for three or more.
conclusionOur findings indicate that both parental subfertility and characteristics related to the ART procedure itself might increase offspring asthma risk, although this needs to be confirmed in future studies, and further suggest that common mechanisms underlying parental subfertility and recurrent miscarriages might influence offspring asthma pathogenesis.
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Registered trials
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