Evidence map›Paper›PMID 30514787›Full record

ArticlemBio2018

The Monothiol Glutaredoxin Grx4 Regulates Iron Homeostasis and Virulence in Cryptococcus neoformans.

Rodgoun Attarian, Guanggan Hu, Eddy Sánchez-León, Mélissa Caza, Daniel Croll, Eunsoo Do, Horacio Bach, Tricia Missall, Jennifer Lodge, Won Hee Jung and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Cryptococcal nutrient acquisition and pathogenesis: dining on the host.Microbiology and molecular biology reviews : MMBR · 2025
    Review
  6. Article
  7. Metals at the Host-Fungal Pathogen Battleground.Annual review of microbiology · 2024
    Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Metals and the cell surface of Cryptococcus neoformans.Current opinion in microbiology · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Rodgoun Attarian *Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Guanggan Hu *Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Eddy Sánchez-LeónMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Mélissa CazaMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Daniel CrollLaboratory of Evolutionary Genetics, Institute of Biology, University of Neuchâtel, Neuchâtel, Switzerland.
Eunsoo DoDepartment of Systems Biotechnology, Chung-Ang University, Anseong, South Korea.
Horacio BachMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada.
Tricia MissallDepartment of Biochemistry, Saint Louis University School of Medicine, St. Louis, Missouri, USA.
Jennifer LodgeDepartment of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Won Hee JungDepartment of Systems Biotechnology, Chung-Ang University, Anseong, South Korea.
James W KronstadMichael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada kronstad@msl.ubc.ca.ORCID 0000-0003-4240-6976
University of British Columbia · CAChung-Ang University · KRSaint Louis University · USUniversity of Neuchâtel · CHWashington University in St. Louis · US

Funding

Comparative and functional genomics of C. neoformansR01AI053721 · NIAID · UNIVERSITY OF BRITISH COLUMBIA · PI KRONSTAD, JAMES W · 2003 to 2024
$5.4M
CIHRNIAID NIH HHS R01 AI053721
6 · The paper itself

Abstract

The acquisition of iron and the maintenance of iron homeostasis are important aspects of virulence for the pathogenic fungus

Indexed as

AnimalsCryptococcosisCryptococcus neoformansFemaleFungal ProteinsGene Expression Regulation, FungalGlutaredoxinsHomeostasisIronMiceMice, Inbred BALB CMutationVirulenceVirulence FactorsFungal ProteinsGlutaredoxinsIronVirulence Factorscapsulecryptococcosismelaninnuclear localizationtranscriptome

Identifiers

PMID30514787
PMCPMC6282196
OpenAlexW2902840085

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.