Evidence map›Paper›PMID 30514783›Full record

ArticlemBio2018

Cryptococcus neoformans, Unlike Candida albicans, Forms Aneuploid Clones Directly from Uninucleated Cells under Fluconazole Stress.

Yun C Chang, Ami Khanal Lamichhane, Kyung J Kwon-Chung

Open access · goldAbstract read
In one paragraph

Article in mBio, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Loss of theMicrobiology spectrum · 2025
    Article
  4. Calcineurin controls the cytokinesis machinery during thermal stress inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Elevated UDP-glucuronic acid levels mend drug resistance and stress responses via a protease and a transporter inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Determination of Ploidy Levels and Nuclear DNA Content inJournal of fungi (Basel, Switzerland) · 2024
    Article
  12. Review
  13. Article
  14. Assessment of Antifungal Pharmacodynamics.Journal of fungi (Basel, Switzerland) · 2023
    Article
  15. A Landscape of the Genomic Structure ofJournal of fungi (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Yun C ChangLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Ami Khanal LamichhaneLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Kyung J Kwon-ChungLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA jkchung@niaid.nih.gov.
National Institutes of Health · US

Funding

Pathogenic differences between Cryptococcus neoformans and C. gattiiZIAAI000744 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KWON-CHUNG, KYUNG · 2010 to 2025
$10.9M
Stress Management of Cryptococcal PathogensZIAAI001042 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI KWON-CHUNG, KYUNG · 2009 to 2025
$9.6M
6 · The paper itself

Abstract

Heteroresistance to fluconazole (FLC) in

Indexed as

AneuploidyAntifungal AgentsCandida albicansCell Cycle ProteinsChromosomal Proteins, Non-HistoneChromosome SegregationCryptococcus neoformansDrug Resistance, FungalFluconazoleMitosisStructural Maintenance of Chromosome Protein 1Time-Lapse ImagingAntifungal AgentsCell Cycle ProteinsChromosomal Proteins, Non-HistoneFluconazoleStructural Maintenance of Chromosome Protein 1aneuploidchromosomal endoduplicationfluconazoleheteroresistancenondisjunction

Identifiers

PMID30514783
PMCPMC6282203
OpenAlexW2902577803

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.