Evidence map›Paper›PMID 30514759›Full record

ArticleThe Journal of biological chemistry2019

Membrane trafficking of the bacterial adhesin GspB and the accessory Sec transport machinery.

Cierra Spencer, Barbara A Bensing, Nagendra N Mishra, Paul M Sullam

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Interactions BetweenFrontiers in cellular and infection microbiology · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Cierra SpencerDivision of Infectious Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121; Department of Medicine, University of California, San Francisco, California 94143.
Barbara A BensingDivision of Infectious Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121; Department of Medicine, University of California, San Francisco, California 94143.
Nagendra N MishraDivision of Infectious Diseases, Los Angeles Biomedical Research Institute, Torrance, California 90502; David Geffen School of Medicine, UCLA, Los Angeles, California 90095.
Paul M SullamDivision of Infectious Diseases, San Francisco Veterans Affairs Medical Center, San Francisco, California 94121; Department of Medicine, University of California, San Francisco, California 94143. Electronic address: paul.sullam@ucsf.edu.
San Francisco VA Medical Center · USUniversity of California, Los Angeles · US

Funding

Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
STREPTOCOCCAL PLATELET BINDING AND ENDOCARDITISR01AI041513 · NIAID · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI SULLAM, PAUL M. · 1997 to 2019
$5.6M
NIAID NIH HHS R01 AI041513NIAID NIH HHS T32 AI060537
6 · The paper itself

Abstract

The serine-rich repeat (SRR) glycoproteins of Gram-positive bacteria are large, cell wall-anchored adhesins that mediate binding to many host cells and proteins and are associated with bacterial virulence. SRR glycoproteins are exported to the cell surface by the accessory Sec (aSec) system comprising SecA2, SecY2, and 3-5 additional proteins (Asp1 to Asp5) that are required for substrate export. These adhesins typically have a 90-amino acid-long signal peptide containing an elongated N-region and a hydrophobic core. Previous studies of GspB (the SRR adhesin of

Indexed as

Adhesins, BacterialAmino Acid SequenceAnionsBacterial ProteinsCell MembraneLipidsProtein BindingProtein Sorting SignalsProtein TransportSEC Translocation ChannelsSequence HomologyStreptococcus gordoniiAdhesins, BacterialAnionsBacterial ProteinsLipidsProtein Sorting SignalsSEC Translocation Channelsaccessory Sec systemadhesinadhesionanionic lipidselectrostatic interactionslipid-protein interactionliposomeprotein targetingprotein translocationsignal peptideStreptococcus

Identifiers

PMID30514759
PMCPMC6364773
OpenAlexW2903023494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.