Evidence map›Paper›PMID 30514758›Full record

ArticleThe Journal of biological chemistry2019

A biosensor-based approach reveals links between efflux pump expression and cell cycle regulation in pleiotropic drug resistance of yeast.

Jian Li, Kristen Kolberg, Ulrich Schlecht, Robert P St Onge, Ana Maria Aparicio, Joe Horecka, Ronald W Davis, Maureen E Hillenmeyer, Colin J B Harvey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Elucidating Bile Acid Tolerance inFoods (Basel, Switzerland) · 2024
    Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jian LiDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Kristen KolbergDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Ulrich SchlechtDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Robert P St OngeDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Ana Maria AparicioDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Joe HoreckaDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Ronald W DavisDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Maureen E HillenmeyerDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304.
Colin J B HarveyDepartment of Biochemistry, Stanford Genome Technology Center, Stanford University School of Medicine, Palo Alto, California 94304. Electronic address: colinjbharvey@gmail.com.
Stanford University · USStanford Medicine · US

Funding

Genomic and synthetic biology tools for expressing natural product gene clustersU01GM110706 · NIGMS · STANFORD UNIVERSITY · PI DAVIS, RONALD WAYNE, STEINMETZ, LARS M · 2014 to 2018
$10.9M
NIGMS NIH HHS U01 GM110706
6 · The paper itself

Abstract

Multidrug resistance is highly conserved in mammalian, fungal, and bacterial cells, is characterized by resistance to several unrelated xenobiotics, and poses significant challenges to managing infections and many cancers. Eukaryotes use a highly conserved set of drug efflux transporters that confer pleiotropic drug resistance (PDR). To interrogate the regulation of this critical process, here we developed a small molecule-responsive biosensor that couples transcriptional induction of PDR genes to growth rate in the yeast

Indexed as

Biosensing TechniquesATP-Binding Cassette TransportersCell Cycle CheckpointsDrug Resistance, MultipleGene Expression Regulation, FungalGenome, FungalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsATP-Binding Cassette TransportersSaccharomyces cerevisiae Proteinsbiosensordrug resistancegene regulationmicroarraymultidrug transporter

Identifiers

PMID30514758
PMCPMC6349095
OpenAlexW2903330522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.