Evidence map›Paper›PMID 30514721›Full record

ArticleMolecular pharmacology2019

Design, Synthesis, and Evaluation of a Diazirine Photoaffinity Probe for Ligand-Based Receptor Capture Targeting G Protein-Coupled Receptors.

Frederike M Müskens, Richard J Ward, Dominik Herkt, Helmus van de Langemheen, Andrew B Tobin, Rob M J Liskamp, Graeme Milligan

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  10. Review
  11. Altering the Sex Pheromone Cyclo(l-Pro-l-Pro) of the DiatomInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Frederike M MüskensSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.
Richard J WardSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.
Dominik HerktSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.
Helmus van de LangemheenSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.
Andrew B TobinSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.
Rob M J LiskampSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0001-8897-8975
Graeme MilliganSchool of Chemistry, College of Science and Engineering (F.M.M., D.H., H.L., R.M.J.L.) and Centre for Translational Pharmacology, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences (F.M.M., R.J.W., A.B.T., G.M.), University of Glasgow, Glasgow, United Kingdom Graeme.Milligan@glasgow.ac.uk Robert.Liskamp@glasgow.ac.uk.ORCID 0000-0002-6946-3519
University of Glasgow · GB

Funding

Medical Research Council MC_UP_A600_1110
6 · The paper itself

Abstract

Chemoproteomic approaches to identify ligand-receptor interactions have gained popularity. However, identifying transmembrane receptors remains challenging. A new trifunctional probe to aid the nonbiased identification of such receptors was developed and synthesized using a convenient seven-step synthesis. This probe contained three functional groups: 1) an

Indexed as

Cell MembraneChromatography, LiquidDiazomethaneHEK293 CellsHumansLigandsReceptors, G-Protein-CoupledReceptors, Neurokinin-1Substance PTandem Mass SpectrometryDiazomethaneLigandsReceptors, G-Protein-CoupledReceptors, Neurokinin-1Substance P

Identifiers

PMID30514721
PMCPMC6324650
OpenAlexW2902200831

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.