ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018
[PSB0739 inhibits formation of semen-derived amyloid fibril].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo explore the inhibitory effect of PSB0739 on the formation of semen-derived amyloid fibrils.
methodsPAP248-286 (440 μmol/L) was incubated with PSB0739 at different concentrations, and at different time points of incubation, aliquots were taken from each sample for Congo red staining to detect the formation of amyloid fibers. The morphology of amyloid fibrils incubated in the presence or absence of PSB0739 was visualized using transmission electron microscope. The effect of PSB0739 on amyloid fibril formation was determined using virus infection assays at different time points, and the surface charges of amyloid fibril incubated with PSB0739 were calculated using a Zeta potentiometer. The cytotoxicity of PSB0739 in Hela cells was determined using MTT assay. The antiviral effect of PSB0738 against HIV- 1 was evaluated by infection assay.
resultsPSB0739 inhibited SEVI fibril formation in a dose-dependent manner
conclusionsPSB0739 can inhibit the formation of semen-derived amyloid fibrils
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