Evidence map›Paper›PMID 30514680›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018

[SIRT1 participates in epithelial-mesenchymal transition of EC-9706 and Eca-109 cells

Yuxiang Wu, Dao Xin, Can Liu, Feng Wang

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Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuxiang WuDepartment of Oncology, First Affiliated Hospital of Nanyang Medical College, Nanyang 473058, China.
Dao XinDepartment of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Can LiuDepartment of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Feng WangDepartment of Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of SIRT1 in the occurrence of epithelial-mesenchymal transition (EMT) in EC-9706 and Eca-109 cells and the possible mechanism.

methodsThree chemically synthesized siRNA targeting SIRT1 were transfected into EC-9706 and Eca-109 cells with the non-transfected cells and cells transfected with the negative siRNAs as controls. Real-time PCR and Western blotting were used to detect the expressions of SIRT1, E-cadherin, vimentin, Snail, Twist1 and ZEB in the cells. Transwell invasion assay and wounding healing assay were used to examine the changes in the invasion and metastasis abilities of the cells after transfection.

resultsEC-9706 and Eca-109 cells transfected with SIRT1 siRNA1 and SIRT1 siRNA3 showed significantly decreased mRNA and protein expressions of SIRT1 (

conclusionsSIRT1 participates in the invasion and metastasis of EC-9706 and Eca- 109 cells probably by inducing EMT via regulating the expression of Snail.

Indexed as

Antigens, CDCadherinsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionHumansNeoplasm InvasivenessNuclear ProteinsRNA, MessengerRNA, Small InterferingSirtuin 1Snail Family Transcription FactorsTransfectionTwist-Related Protein 1VimentinZinc Finger E-box-Binding Homeobox 1Antigens, CDCadherinsCDH1 protein, humanNuclear ProteinsRNA, MessengerRNA, Small InterferingSirtuin 1Snail Family Transcription FactorsTWIST1 protein, humanTwist-Related Protein 1VimentinZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1epithelial-mesenchymal transitionesophageal carcinomainvasion and metastasisSIRT1Snail

Identifiers

PMID30514680
PMCPMC6744119
OpenAlexW2907825337

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.