Evidence map›Paper›PMID 30514679›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018

[Establishment of a rat model of dimethylbenzanthracene-induced vulvar squamous intraepithelial lesions].

Yijin Fan, Huajun Tang, Yao Liu, Chengzhi Li

Abstract read
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In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yijin FanCollege of Biomedical Engineering, Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology/Chongqing Key Laboratory of Biomedical Engineering/ Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, Chongqing 400016, China.
Huajun TangCollege of Biomedical Engineering, Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology/Chongqing Key Laboratory of Biomedical Engineering/ Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, Chongqing 400016, China.
Yao LiuCollege of Biomedical Engineering, Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology/Chongqing Key Laboratory of Biomedical Engineering/ Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, Chongqing 400016, China.
Chengzhi LiCollege of Biomedical Engineering, Chongqing Medical University/State Key Laboratory of Ultrasound Engineering in Medicine Co-Founded by Chongqing and the Ministry of Science and Technology/Chongqing Key Laboratory of Biomedical Engineering/ Chongqing Collaborative Innovation Center for Minimally Invasive and Noninvasive Medicine, Chongqing 400016, China.
Chongqing University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo establish a SD rat model of vulvar squamous intraepithelial lesions.

methodsSeventy female SD rats were randomized into 4 groups, namely the blank control group (

resultsNo significant differences were found in the morphological or histopathological changes of the skin among the blank control group, mechanical irritation group and acetone solution group. In the model group, low-grade squamous intraepithelial lesions (LSIL) occurred in 28 rats (70%) and high-grade squamous intraepithelial lesions (HSIL) in 11 rats (27.5%) at 14 weeks, with a success rate of 97.5% in inducing vulvar squamous intraepithelial lesions. Compared with the blank control group, the rats in the model group showed significantly increased expressions of mtp53 and VEGF at both the protein level (

conclusionsDMBA in acetone solution combined with mechanical irritation can induce vulvar squamous intraepithelial lesions in female SD rats.

Indexed as

Disease Models, Animal9,10-Dimethyl-1,2-benzanthraceneAcetoneAnimalsBlotting, WesternCarcinogensFemaleFrictionImmunohistochemistryPrecancerous ConditionsRandom AllocationRatsRats, Sprague-DawleySkinSolventsTumor Suppressor Protein p539,10-Dimethyl-1,2-benzanthraceneAcetoneCarcinogensSolventsTumor Suppressor Protein p53Vascular Endothelial Growth Factor Avascular endothelial growth factor A, ratanimal modeldimethylbenzanthracenevulvar squamous intraepithelial lesion

Identifiers

PMID30514679
PMCPMC6744125
OpenAlexW3024101420

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.