Evidence map›Paper›PMID 30514677›Full record

ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2018

[Role of mitochondrial permeability transition pore in mediating the inhibitory effect of gastrodin on oxidative stress in cardiac myocytes

Xuechao Han, Jingman Xu, Sen Xu, Yahan Sun, Mali He, Xiaodong Li, Xinyu Li, Jiayi Pi, Rui Yu, Wei Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Food science & nutrition · 2025
    Article
  2. Evidence-based complementary and alternative medicine : eCAM · 2023
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Xuechao HanMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Jingman XuMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Sen XuMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Yahan SunMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Mali HeMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Xiaodong LiMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Xinyu LiMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Jiayi PiMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Rui YuMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
Wei TianMedical Research Center (International Scientific and Technological Cooperation Base of Geriatrics Medicine), North China University of Science and Technology, Tangshan 063000, China.
North China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of mitochondrial permeability transition pore (mPTP) in mediating the protective effect of gastrodin against oxidative stress damage in H9c2 cardiac myocytes.

methodsH9c2 cardiac myocytes were treated with H

resultsGastrodin pretreatment could prevent oxidative stress-induced reduction of mitochondrial membrane potential, and this effect was inhibited by the application of CsA. Gastrodin significantly lowered the levels of ROS and apoptosis-related factors in H

conclusionsGastrodin prevents oxidative stress-induced injury in H9c2 cells by inhibiting mPTP opening to reduce the cell apoptosis.

Indexed as

Oxidative StressAdenosine TriphosphateApoptosisBenzyl AlcoholsCaspase 3Cell LineCell SurvivalCyclosporineCytochromes cGlucosidesHumansHydrogen PeroxideMembrane Potential, MitochondrialMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocytes, CardiacAdenosine TriphosphateBenzyl AlcoholsCaspase 3CyclosporineCytochromes cgastrodinGlucosidesHydrogen PeroxideMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreReactive Oxygen Speciescyclosporingastrodinmitochondrial permeability transition poreoxidative stress injury

Identifiers

PMID30514677
PMCPMC6744122
OpenAlexW2997182086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.