Evidence map›Paper›PMID 30514355›Full record

ArticleParasites & vectors2018

"Candidatus Neoehrlichia mikurensis" in Ixodes ricinus ticks collected near the Arctic Circle in Norway.

Clarinda Larsson, Dag Hvidsten, Snorre Stuen, Anna J Henningsson, Peter Wilhelmsson

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  7. Pathogens (Basel, Switzerland) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Clarinda LarssonFaculty of Medicine and Health Sciences, Linköping University, Linköping, Sweden.
Dag HvidstenDepartment of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway.
Snorre StuenDepartment of Production Animal Clinical Sciences, Section of Small Ruminant Research and Herd Health, Norwegian University of Life Sciences, Sandnes, Norway.
Anna J HenningssonClinical Microbiology, Laboratory Medicine, County Hospital Ryhov, Jönköping, Sweden.
Peter WilhelmssonDivision of Medical Microbiology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. peter.wilhelmsson@liu.se.
Linköping University · SENordland Hospital · NONorwegian University of Life Sciences · NORyhov Hospital Jönköping · SE

Funding

EU Interreg V program ScandTick Innovation Project ID: 20200422Helse Nord RHF SFP912-10Scandinavian Society for Antimicrobial Therapy SLS-100221The Medical Research Council of Southeast Sweden FORSS-657881
6 · The paper itself

Abstract

background"Candidatus Neoehrlichia mikurensis" is a gram-negative bacterium belonging to the family Anaplasmataceae that, in Europe, is transmitted by Ixodes ricinus ticks. "Candidatus N. mikurensis" can cause a severe systemic inflammatory syndrome, neoehrlichiosis, mostly in persons with other underlying diseases. To date, "Ca. N. mikurensis" has been found in ticks in different countries in Asia and Europe, but never as far north as at the Arctic Circle.

methodsA total of 1104 I. ricinus ticks collected from vegetation and from animals in northern Norway (64-68°N) were analysed for the prevalence of "Ca. N. mikurensis". Of them, 495 ticks were collected from vegetation by flagging and 609 ticks were collected from dogs and cats. Total nucleic acid extracted from the ticks were converted to cDNA and analyzed with real-time PCR targeting the 16S rRNA gene of "Ca. N. mikurensis". Positive samples were further analysed by nested PCR and sequencing.

results"Candidatus N. mikurensis" was detected in 11.2% of all collected I. ricinus ticks in northern Norway. The prevalence differed between ticks collected from vegetation (18.2%; 90/495) compared to ticks collected from dogs and cats (5.6%; 34/609). The ticks from dogs and cats were collected in Brønnøy area and seven additional districts further north. The prevalence of "Ca. N. mikurensis" in these ticks differed between geographical localities, with the highest prevalence in the Brønnøy area.

conclusionsThe detection of "Ca. N. mikurensis" in I. ricinus ticks from the Arctic Circle in northern Norway indicates potential risk for tick-bitten humans at this latitude to be infected with "Ca. N. mikurensis".

Indexed as

AnaplasmataceaeAnaplasmataceae InfectionsAnimalsCatsDNA, BacterialDogsFemaleIxodesMaleNorwayPrevalenceRNA, Ribosomal, 16SDNA, BacterialRNA, Ribosomal, 16SArctic Circle“Candidatus Neoehrlichia mikurensis”Ixodes ricinusNeoehrlichiosisNorwayTick-borne pathogen

Identifiers

PMID30514355
PMCPMC6278014
OpenAlexW2903412331

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.