Evidence map›Paper›PMID 30514306›Full record

ArticleHarm reduction journal2018

The complex relation between access to opioid agonist therapy and diversion of opioid medications: a case example of large-scale misuse of buprenorphine in the Czech Republic.

Viktor Mravčík, Barbara Janíková, Barbora Drbohlavová, Petr Popov, Alessandro Pirona

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Harm reduction journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Viktor MravčíkDepartment of Addictology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic. mravcik.viktor@vlada.cz.ORCID 0000-0001-5062-5744
Barbara JaníkováDepartment of Addictology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Barbora DrbohlavováDepartment of Addictology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Petr PopovDepartment of Addictology, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic.
Alessandro PironaEuropean Monitoring Centre for Drugs and Drug Addiction, Lisbon, Portugal.
Charles University · CZEuropean Monitoring Centre for Drugs and Drug Addiction · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opioid agonist therapy (OAT) has been available in a standard regime in the Czech Republic since 2000. Buprenorphine is the leading medication, while methadone is available only in a few specialised centres. There is an important leakage of buprenorphine onto the illicit market, and the majority of Czech opioid users are characterised by the misuse (and injecting) of diverted buprenorphine medications. Most prescribed buprenorphine for OAT is not covered by current national health insurance schemes, and patients have to pay considerable prices to afford their treatment. This affordability barrier together with limited accessibility is likely the leading factor of limited coverage of OAT and of recent stagnation in the number of patients in the official treatment programmes in the Czech Republic. It also encourages doctor shopping and the re-selling of parts of their medication at a higher price, which represents the main factor that drives the Czech illicit market for buprenorphine, but at the same time co-finances the medication of clients in official OAT programmes. Improving access to OAT by making it financially affordable is essential to further increase OAT coverage and is one of the factors that can reduce the illicit market with OAT medications.

Indexed as

Analgesics, OpioidBuprenorphineAdolescentAdultCzech RepublicFemaleHealth Services AccessibilityHumansIllicit DrugsMaleMethadoneMiddle AgedNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersSubstance-Related DisordersAnalgesics, OpioidBuprenorphineIllicit DrugsMethadoneNarcoticsAccessAvailabilityBarriersBuprenorphineCostCrimeDiversionHeroinIllicit marketMortalityOpioidsOpioid substitution treatment

Identifiers

PMID30514306
PMCPMC6280526
OpenAlexW2902327895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.