Evidence map›Paper›PMID 30514242›Full record

ArticleBMC neurology2018

Increased serum exosomal miR-134 expression in the acute ischemic stroke patients.

Jingxia Zhou, Lin Chen, Bocan Chen, Shaozhu Huang, Chaosheng Zeng, Hairong Wu, Cong Chen, Faqing Long

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 4 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 4 syntheses or guidelines pooled it, 105 citations in OpenAlex.

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  4. Exosomes in pathogenesis, diagnosis, and therapy of ischemic stroke.Frontiers in bioengineering and biotechnology · 2022
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jingxia ZhouDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Lin ChenDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Bocan ChenDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Shaozhu HuangDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Chaosheng ZengDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Hairong WuDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Cong ChenDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China.
Faqing LongDepartment of Neurology, The Second Affiliated Hospital of Hainan Medical University, Haikou, 570311, Hainan Province, People's Republic of China. drctorlong@aliyun.com.ORCID http://orcid.org/0000-0003-4862-1423
Hainan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe exosomal miRNAs have been emerged as biomarkers and therapeutic targets for various diseases, however, the function of exosomal miRNAs in stroke remains largely unknown.

methodsThe blood samples from acute ischemic stroke (AIS) patients and normal controls were collected. The exosomes were isolated from the blood samples, which were confirmed by electron microscopy and western blot with the specific exosomes biomarker CD9, CD63 and Tsg101.

resultsRT-qPCR analysis showed that exosomal miR-134 was significantly increased in AIS patients within 24 h after stroke onset compared with that of control group. Highly expressed exosomal miR-134 was correlated with the National Institutes of Health Stroke Scale (NIHSS) scores, infarct volume and positively associated with the worse prognosis of the stroke patients. Additionally, the exosomal miR-134 was strong positively correlated with the expression of serum interleukin 6 (IL-6) and plasma high-sensitivity C relative protein (hs-CRP). The receiver operating characteristic (ROC) curve suggested that miR-134 might be a potential factor to discriminate AIS patients from non-stroke controls.

conclusionsThe exosomal miR-134 as a possible novel biomarker for the diagnosis and prognosis of stroke.

Indexed as

AgedBiomarkersExosomesFemaleHumansInterleukin-6MaleMicroRNAsMiddle AgedPrognosisROC CurveSensitivity and SpecificityStrokeUnited StatesBiomarkersInterleukin-6MicroRNAsMIRN134 microRNA, humanAcute ischemic strokeExosomeInfarct volumemiR-134National Institutes of Health stroke scale scores

Identifiers

PMID30514242
PMCPMC6278025
OpenAlexW2903555532

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.