Evidence map›Paper›PMID 30513973›Full record

ReviewMolecules (Basel, Switzerland)2018

Natural Negative Allosteric Modulators of 5-HT₃ Receptors.

Lina T Al Kury, Mohamed Mahgoub, Frank Christopher Howarth, Murat Oz

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. 5-HTCurrent neuropharmacology · 2021
    Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The Polypharmacological Effects of Cannabidiol.Molecules (Basel, Switzerland) · 2023
    Review
  9. Review
  10. Serotonin and beyond-a tribute to Manfred Göthert (1939-2019).Naunyn-Schmiedeberg's archives of pharmacology · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Lina T Al KuryDepartment of Health Sciences, College of Natural and Health Sciences, Zayed University, 144534 Abu Dhabi, United Arab Emirates. Lina.AlKury@zu.ac.ae.ORCID 0000-0002-8338-7655
Mohamed MahgoubDepartments of Pharmacology, College of Medicine and Health Sciences, UAE University, 15551 Al Ain, United Arab Emirates. mahjoub_mohd@live.com.
Frank Christopher HowarthDepartments of Physiology, College of Medicine and Health Sciences, UAE University, 15551 Al Ain, United Arab Emirates. chris.howarth@uaeu.ac.ae.
Murat OzDepartment of Pharmacology and Therapeutics, Faculty of Pharmacy, Kuwait University, 13060 Kuwait. muratoz1@yahoo.com.
United Arab Emirates University · AEKuwait University · KWZayed University · AE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT

Indexed as

Allosteric RegulationAntineoplastic AgentsBinding SitesCannabidiolHumansNauseaReceptors, Serotonin, 5-HT3Serotonin 5-HT3 Receptor AntagonistsTerpenesVomitingZingiber officinaleAntineoplastic AgentsCannabidiolReceptors, Serotonin, 5-HT3Serotonin 5-HT3 Receptor AntagonistsTerpenes5-hydroxytryptamine3 receptor antagonists5-hydroxytryptamine3 receptorschemotherapy-induced nausea and vomitingnegative allosteric modulators

Identifiers

PMID30513973
PMCPMC6321066
OpenAlexW2902560652

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.