ArticleSensors (Basel, Switzerland)2018
Suppression Technique of HeLa Cell Proliferation Using Ultrasonic Power Amplifiers Integrated with a Series-Diode Linearizer.
Article in Sensors (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Sonomechanobiology: Vibrational stimulation of cells and its therapeutic implications.Biophysics reviews · 2023Review
- Harmonic-Reduced Bias Circuit for Ultrasound Transducers.Sensors (Basel, Switzerland) · 2023Article
- An Inverse Class-E Power Amplifier for Ultrasound Transducer.Sensors (Basel, Switzerland) · 2023Article
- A Doherty Power Amplifier for Ultrasound Instrumentation.Sensors (Basel, Switzerland) · 2023Article
- Biological Effects and Applications of Bulk and Surface Acoustic Waves on In Vitro Cultured Mammal Cells: New Insights.Biomedicines · 2022Review
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- Fisheye lens design for solar-powered mobile ultrasound devices.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- Novel dual-resistor-diode limiter circuit structures for high-voltage reliable ultrasound receiver systems.Technology and health care : official journal of the European Society for Engineering and Medicine · 2022Article
- A New Approach to Power Efficiency Improvement of Ultrasonic Transmitters via a Dynamic Bias Technique.Sensors (Basel, Switzerland) · 2021Article
- Novel Bandwidth Expander Supported Power Amplifier for Wideband Ultrasound Transducer Devices.Sensors (Basel, Switzerland) · 2021Article
- Development of a low-cost six-axis alignment instrument for flexible 2D and 3D ultrasonic probes.Technology and health care : official journal of the European Society for Engineering and Medicine · 2021Article
- Inter-Stage Output Voltage Amplitude Improvement Circuit Integrated with Class-B Transmit Voltage Amplifier for Mobile Ultrasound Machines.Sensors (Basel, Switzerland) · 2020Article
- Post-Voltage-Boost Circuit-Supported Single-Ended Class-B Amplifier for Piezoelectric Transducer Applications.Sensors (Basel, Switzerland) · 2020Article
- Wireless Ultrasound Surgical System with Enhanced Power and Amplitude Performances.Sensors (Basel, Switzerland) · 2020Article
- Development of an Accurate Resonant Frequency Controlled Wire Ultrasound Surgical Instrument.Sensors (Basel, Switzerland) · 2020Article
- Wide Bandwidth Class-S Power Amplifiers for Ultrasonic Devices.Sensors (Basel, Switzerland) · 2020Article
- A Macro Lens-Based Optical System Design for Phototherapeutic Instrumentation.Sensors (Basel, Switzerland) · 2019Article
- Stacked Transistor Bias Circuit of Class-B Amplifier for Portable Ultrasound Systems.Sensors (Basel, Switzerland) · 2019Article
- Development of a Class-C Power Amplifier with Diode Expander Architecture for Point-of-Care Ultrasound Systems.Micromachines · 2019Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
A series-diode linearizer scheme is developed, which can possibly generate higher voltage signals. To verify our proposed concept, ultrasonic power amplifiers with and without the linearizer were tested for HeLa cells proliferation in vitro. In general, ultrasonic stimulus initiates the process of cavitation which can cause cell lysis and disruption of cell attachment. The cavitation can also induce formation of free radicals so that a rigid membrane of malignant cancer cells have increased sensitivity to ultrasonic stimulus. The cell density of the control group increased up to almost 100% on Day 3. However, cell densities of the experimental group when using an isolated ultrasonic power amplifier, and ultrasonic power amplifiers integrated with the linearizer at 1 V and 5 V DC (direct current) bias could be suppressed more than that when using an ultrasonic power amplifier (90.7 ± 1.2%, 75.8 ± 3.5%, and 68.1 ± 1.1%, respectively). Additionally, the proliferation suppressing ratios of each experimental group confirmed that the cell density decrements of the experimental groups exhibited statistical significance compared to the control group (ultrasonic power amplifier = 8.87%, ultrasonic power amplifier with 1 V biased linearizer = 23.87%, and ultrasonic power amplifier with 5 V biased linearizer = 31.56%).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.